MicroRNA-mediated regulation of KRAS in cancer

While microRNAs (miRNAs) and the KRAS oncogene are known to be dysregulated in various cancers, little is known about the role of miRNAs in the regulation of KRAS in cancer. Here we review a selection of studies published in 2014 that have contributed to our understanding of the molecular mechanisms...

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Bibliographic Details
Published in:Journal of hematology and oncology 2014-11, Vol.7 (1), p.84-84, Article 84
Main Authors: Kim, Minlee, Slack, Frank J
Format: Article
Language:English
Subjects:
Analysis
Animals
Apoptosis
Breast cancer
Cancer
Care and treatment
Cell cycle
Cell differentiation
Colorectal cancer
Development and progression
Diagnosis
Gene Expression Regulation, Neoplastic
Genes, ras
Genetic aspects
Genetic translation
Hematology
Humans
Kinases
Lung cancer
MicroRNA
MicroRNAs
MicroRNAs - genetics
Neoplasms - genetics
Oncology
Oncology, Experimental
Pancreatic cancer
Polymorphism, Single Nucleotide
Proteins
Proto-Oncogene Proteins - genetics
Proto-Oncogene Proteins p21(ras)
ras Proteins - genetics
Research Highlight
Risk factors
Single nucleotide polymorphisms
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Summary:While microRNAs (miRNAs) and the KRAS oncogene are known to be dysregulated in various cancers, little is known about the role of miRNAs in the regulation of KRAS in cancer. Here we review a selection of studies published in 2014 that have contributed to our understanding of the molecular mechanisms of KRAS regulation by miRNAs and the clinical relevance of sequence variants that may interfere with functional miRNA-mediated KRAS regulation.
ISSN:1756-8722
1756-8722
DOI:10.1186/s13045-014-0084-2