Optimal single-dose epidural neostigmine for postoperative analgesia after partial hepatectomy

Neostigmine can produce analgesia by acting on the spinal cord. This study was to determine the optimal single-dose of epidural neostigmine for postoperative analgesia after partial hepatectomy. Twenty-six patients undergoing elective partial hepatectomy under general anesthesia combined with epidur...

Full description

Saved in:
Bibliographic Details
Published in:Indian journal of pharmacology 2014-11, Vol.46 (6), p.613-616
Main Authors: Zhong, Qiao Sheng, Ge, Sheng Jin, Wang, Bei, Xue, Zhang Gang
Format: Article
Language:English
Subjects:
Adolescent
Adult
Analgesia
Analgesia, Epidural
Analgesia, Patient-Controlled
Analgesics - administration & dosage
Analgesics - therapeutic use
Complications
Complications and side effects
Dosage and administration
Dose-Response Relationship, Drug
Drug therapy
Female
Hepatectomy
Humans
Injections, Epidural
Male
Middle Aged
Neostigmine
Neostigmine - administration & dosage
Neostigmine - therapeutic use
Surgery
Young Adult
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Neostigmine can produce analgesia by acting on the spinal cord. This study was to determine the optimal single-dose of epidural neostigmine for postoperative analgesia after partial hepatectomy. Twenty-six patients undergoing elective partial hepatectomy under general anesthesia combined with epidural block were studied. The dose of epidural neostigmine was determined using Dixon's up-and-down method, starting from neostigmine 100 μg with an interval of 25 μg. Thirty minutes after skin incision, a predetermined dose of neostigmine was injected via the epidural catheter. Each patient received 0.125% bupivacaine and fentanyl 2 μg/ml for patient controlled epidural analgesia (PCEA) after the operation. Assessment of analgesia quality was performed at 8 h and 24 h after the operation. The ED50 of epidural neostigmine in combination with PCEA for satisfactory analgesia was 226.78 ± 33.20 μg. Probit analysis showed that the ED50 and ED95 of epidural neostigmine were 228.63 μg (95% CI = 197.95-299.77 μg) and 300.12 μg (95% CI = 259.44-741.65 μg), respectively. The ED50 and ED95 of epidural neostigmine in combination with PCEA for satisfactory analgesia after partial hepatectomy were 228.63 μg (95% CI = 197.95-299.77 μg) and 300.12 μg (95% CI = 259.44-741.65 μg).
ISSN:0253-7613
1998-3751
DOI:10.4103/0253-7613.144918