Alternative splicing of DNA damage response genes and gastrointestinal cancers

Alternative splicing,which is a common phenomenon in mammalian genomes,is a fundamental process of gene regulation and contributes to great protein diversity.Alternative splicing events not only occur in the normal gene regulation process but are also closely related to certain diseases including ca...

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Bibliographic Details
Published in:World journal of gastroenterology : WJG 2014-12, Vol.20 (46), p.17305-17313
Main Authors: Rahmutulla, Bahityar, Matsushita, Kazuyuki, Nomura, Fumio
Format: Article
Language:English
Subjects:
Alternative
Alternative Splicing
Animals
Biomarkers, Tumor - genetics
damage
DNA
DNA Damage - genetics
DNA Repair - genetics
Gastrointestinal
Gastrointestinal Neoplasms - genetics
Gastrointestinal Neoplasms - pathology
Gastrointestinal Neoplasms - therapy
Gene Expression Regulation, Neoplastic
Genetic Predisposition to Disease
Genomic Instability
Humans
Molecular Diagnostic Techniques
Mutation
Predictive Value of Tests
Prognosis
Risk Factors
splicing
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Summary:Alternative splicing,which is a common phenomenon in mammalian genomes,is a fundamental process of gene regulation and contributes to great protein diversity.Alternative splicing events not only occur in the normal gene regulation process but are also closely related to certain diseases including cancer.In this review,we briefly demonstrate the concept of alternative splicing and DNA damage and describe the association of alternative splicing and cancer pathogenesis,focusing on the potential relationship of alternative splicing,DNA damage,and gastrointestinal cancers.We will also discuss whether alternative splicing leads to genetic instability,which is considered to be a driving force for tumorigenesis.Better understanding of the role and mechanism of alternative splicing in tumorigenesis may provide new directions for future cancer studies.
ISSN:1007-9327
2219-2840
DOI:10.3748/wjg.v20.i46.17305