Physiology of leptin: energy homeostasis, neuroendocrine function and metabolism

Abstract Leptin is secreted by adipose tissue and regulates energy homeostasis, neuroendocrine function, metabolism, immune function and other systems through its effects on the central nervous system and peripheral tissues. Leptin administration has been shown to restore metabolic and neuroendocrin...

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Bibliographic Details
Published in:Metabolism, clinical and experimental clinical and experimental, 2015-01, Vol.64 (1), p.24-34
Main Authors: Park, Hyeong-Kyu, Ahima, Rexford S
Format: Article
Language:English
Subjects:
Animals
Endocrinology & Metabolism
Energy homeostasis
Energy Metabolism - physiology
Homeostasis - physiology
Humans
Hypothalamus
Leptin
Leptin - metabolism
Metabolic Diseases - metabolism
Metabolic Diseases - physiopathology
Metabolism
Neurosecretory Systems - metabolism
Neurosecretory Systems - physiology
Obesity
Obesity - metabolism
Obesity - physiopathology
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Summary:Abstract Leptin is secreted by adipose tissue and regulates energy homeostasis, neuroendocrine function, metabolism, immune function and other systems through its effects on the central nervous system and peripheral tissues. Leptin administration has been shown to restore metabolic and neuroendocrine abnormalities in individuals with leptin-deficient states, including hypothalamic amenorrhea and lipoatrophy. In contrast, obese individuals are resistant to leptin. Recombinant leptin is beneficial in patients with congenital leptin deficiency or generalized lipodystrophy. However, further research on molecular mediators of leptin resistance is needed for the development of targeted leptin sensitizing therapies for obesity and related metabolic diseases.
ISSN:0026-0495
1532-8600
DOI:10.1016/j.metabol.2014.08.004