Mixing Signals: Molecular Turn Ons and Turn Offs for Innate γδ T-Cells

Lymphocytes of the gamma delta (γδ) T-cell lineage are evolutionary conserved and although they express rearranged antigen-specific receptors, a large proportion respond as innate effectors. γδ T-cells are poised to combat infection by responding rapidly to cytokine stimuli similar to innate lymphoi...

Full description

Saved in:
Bibliographic Details
Published in:Frontiers in immunology 2014, Vol.5, p.654-654
Main Authors: Bekiaris, Vasileios, Šedý, John R, Ware, Carl F
Format: Article
Language:English
Subjects:
Immunology
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Lymphocytes of the gamma delta (γδ) T-cell lineage are evolutionary conserved and although they express rearranged antigen-specific receptors, a large proportion respond as innate effectors. γδ T-cells are poised to combat infection by responding rapidly to cytokine stimuli similar to innate lymphoid cells. This potential to initiate strong inflammatory responses necessitates that inhibitory signals are balanced with activation signals. Here, we discuss some of the key mechanisms that regulate the development, activation, and inhibition of innate γδ T-cells in light of recent evidence that the inhibitory immunoglobulin-superfamily member B and T lymphocyte attenuator restricts their differentiation and effector function.
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2014.00654