Expression of PBK/TOPK in cervical cancer and cervical intraepithelial neoplasia

objectives: To evaluate the expression of PBK/TOPK (PDZ-binding kinase/T-LAK cell-originated protein kinase) and its clinical significance in cervical cancer and cervical intraepithelial neoplasia. PBK/TOPK expression was detected in 28 cases of low-grade cervical intraepithelial neoplasia (CINI), 6...

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Bibliographic Details
Published in:International journal of clinical and experimental pathology 2014-01, Vol.7 (11), p.8059-8064
Main Authors: Luo, Qiong, Lei, Bin, Liu, Shuguang, Chen, Yaowen, Sheng, Wenjie, Lin, Peixin, Li, Wenxia, Zhu, Haili, Shen, Hong
Format: Article
Language:English
Subjects:
Adult
Biomarkers, Tumor - metabolism
Carcinoma, Squamous Cell - metabolism
Carcinoma, Squamous Cell - pathology
Cervical Intraepithelial Neoplasia - metabolism
Cervical Intraepithelial Neoplasia - pathology
Female
Humans
Immunohistochemistry
Lymphatic Metastasis - pathology
Middle Aged
Mitogen-Activated Protein Kinase Kinases - metabolism
Neoplasm Grading
Neoplasm Invasiveness - pathology
Neoplasm Staging
Original
Uterine Cervical Neoplasms - metabolism
Uterine Cervical Neoplasms - pathology
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Summary:objectives: To evaluate the expression of PBK/TOPK (PDZ-binding kinase/T-LAK cell-originated protein kinase) and its clinical significance in cervical cancer and cervical intraepithelial neoplasia. PBK/TOPK expression was detected in 28 cases of low-grade cervical intraepithelial neoplasia (CINI), 62 cases of high-grade intraepithelial neoplasia and 80 cases of cervical cancer by immunohistochemistry (IHC). Then, the correlation between PBK/TOPK expression and clinicopathological features was quantitatively analyzed by measuring the positive unit (PU). PBK/TOPK expression was significantly greater in cervical cancer than that in high-grade intraepithelial neoplasia and CINI (P < 0.05). Meanwhile, PBK/TOPK expression in high-grade intraepithelial neoplasia was significantly higher compared with that in CINI (P < 0.05). In addition, PBK/TOPK expression in cervical cancer significantly correlated with histological type, differentiation, lymph node metastasis, vaginal and cervical invasion, TNM stage and tumor size (P < 0.05). PBK/TOPK expression is closely associated with cervical cancer and cervical intraepithelial neoplasia, which may be served as a useful target for tumor diagnosis and immunotherapy.
ISSN:1936-2625