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Expression of PBK/TOPK in cervical cancer and cervical intraepithelial neoplasia
objectives: To evaluate the expression of PBK/TOPK (PDZ-binding kinase/T-LAK cell-originated protein kinase) and its clinical significance in cervical cancer and cervical intraepithelial neoplasia. PBK/TOPK expression was detected in 28 cases of low-grade cervical intraepithelial neoplasia (CINI), 6...
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| Published in: | International journal of clinical and experimental pathology 2014-01, Vol.7 (11), p.8059-8064 |
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| Main Authors: | , , , , , , , , |
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| Language: | English |
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| container_end_page | 8064 |
| container_issue | 11 |
| container_start_page | 8059 |
| container_title | International journal of clinical and experimental pathology |
| container_volume | 7 |
| creator | Luo, Qiong Lei, Bin Liu, Shuguang Chen, Yaowen Sheng, Wenjie Lin, Peixin Li, Wenxia Zhu, Haili Shen, Hong |
| description | objectives: To evaluate the expression of PBK/TOPK (PDZ-binding kinase/T-LAK cell-originated protein kinase) and its clinical significance in cervical cancer and cervical intraepithelial neoplasia.
PBK/TOPK expression was detected in 28 cases of low-grade cervical intraepithelial neoplasia (CINI), 62 cases of high-grade intraepithelial neoplasia and 80 cases of cervical cancer by immunohistochemistry (IHC). Then, the correlation between PBK/TOPK expression and clinicopathological features was quantitatively analyzed by measuring the positive unit (PU).
PBK/TOPK expression was significantly greater in cervical cancer than that in high-grade intraepithelial neoplasia and CINI (P < 0.05). Meanwhile, PBK/TOPK expression in high-grade intraepithelial neoplasia was significantly higher compared with that in CINI (P < 0.05). In addition, PBK/TOPK expression in cervical cancer significantly correlated with histological type, differentiation, lymph node metastasis, vaginal and cervical invasion, TNM stage and tumor size (P < 0.05).
PBK/TOPK expression is closely associated with cervical cancer and cervical intraepithelial neoplasia, which may be served as a useful target for tumor diagnosis and immunotherapy. |
| format | article |
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PBK/TOPK expression was detected in 28 cases of low-grade cervical intraepithelial neoplasia (CINI), 62 cases of high-grade intraepithelial neoplasia and 80 cases of cervical cancer by immunohistochemistry (IHC). Then, the correlation between PBK/TOPK expression and clinicopathological features was quantitatively analyzed by measuring the positive unit (PU).
PBK/TOPK expression was significantly greater in cervical cancer than that in high-grade intraepithelial neoplasia and CINI (P < 0.05). Meanwhile, PBK/TOPK expression in high-grade intraepithelial neoplasia was significantly higher compared with that in CINI (P < 0.05). In addition, PBK/TOPK expression in cervical cancer significantly correlated with histological type, differentiation, lymph node metastasis, vaginal and cervical invasion, TNM stage and tumor size (P < 0.05).
PBK/TOPK expression is closely associated with cervical cancer and cervical intraepithelial neoplasia, which may be served as a useful target for tumor diagnosis and immunotherapy.</description><identifier>EISSN: 1936-2625</identifier><identifier>PMID: 25550851</identifier><language>eng</language><publisher>United States: e-Century Publishing Corporation</publisher><subject>Adult ; Biomarkers, Tumor - metabolism ; Carcinoma, Squamous Cell - metabolism ; Carcinoma, Squamous Cell - pathology ; Cervical Intraepithelial Neoplasia - metabolism ; Cervical Intraepithelial Neoplasia - pathology ; Female ; Humans ; Immunohistochemistry ; Lymphatic Metastasis - pathology ; Middle Aged ; Mitogen-Activated Protein Kinase Kinases - metabolism ; Neoplasm Grading ; Neoplasm Invasiveness - pathology ; Neoplasm Staging ; Original ; Uterine Cervical Neoplasms - metabolism ; Uterine Cervical Neoplasms - pathology</subject><ispartof>International journal of clinical and experimental pathology, 2014-01, Vol.7 (11), p.8059-8064</ispartof><rights>IJCEP Copyright © 2014 2014</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4270522/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4270522/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25550851$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Luo, Qiong</creatorcontrib><creatorcontrib>Lei, Bin</creatorcontrib><creatorcontrib>Liu, Shuguang</creatorcontrib><creatorcontrib>Chen, Yaowen</creatorcontrib><creatorcontrib>Sheng, Wenjie</creatorcontrib><creatorcontrib>Lin, Peixin</creatorcontrib><creatorcontrib>Li, Wenxia</creatorcontrib><creatorcontrib>Zhu, Haili</creatorcontrib><creatorcontrib>Shen, Hong</creatorcontrib><title>Expression of PBK/TOPK in cervical cancer and cervical intraepithelial neoplasia</title><title>International journal of clinical and experimental pathology</title><addtitle>Int J Clin Exp Pathol</addtitle><description>objectives: To evaluate the expression of PBK/TOPK (PDZ-binding kinase/T-LAK cell-originated protein kinase) and its clinical significance in cervical cancer and cervical intraepithelial neoplasia.
PBK/TOPK expression was detected in 28 cases of low-grade cervical intraepithelial neoplasia (CINI), 62 cases of high-grade intraepithelial neoplasia and 80 cases of cervical cancer by immunohistochemistry (IHC). Then, the correlation between PBK/TOPK expression and clinicopathological features was quantitatively analyzed by measuring the positive unit (PU).
PBK/TOPK expression was significantly greater in cervical cancer than that in high-grade intraepithelial neoplasia and CINI (P < 0.05). Meanwhile, PBK/TOPK expression in high-grade intraepithelial neoplasia was significantly higher compared with that in CINI (P < 0.05). In addition, PBK/TOPK expression in cervical cancer significantly correlated with histological type, differentiation, lymph node metastasis, vaginal and cervical invasion, TNM stage and tumor size (P < 0.05).
PBK/TOPK expression is closely associated with cervical cancer and cervical intraepithelial neoplasia, which may be served as a useful target for tumor diagnosis and immunotherapy.</description><subject>Adult</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Carcinoma, Squamous Cell - metabolism</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Cervical Intraepithelial Neoplasia - metabolism</subject><subject>Cervical Intraepithelial Neoplasia - pathology</subject><subject>Female</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Lymphatic Metastasis - pathology</subject><subject>Middle Aged</subject><subject>Mitogen-Activated Protein Kinase Kinases - metabolism</subject><subject>Neoplasm Grading</subject><subject>Neoplasm Invasiveness - pathology</subject><subject>Neoplasm Staging</subject><subject>Original</subject><subject>Uterine Cervical Neoplasms - metabolism</subject><subject>Uterine Cervical Neoplasms - pathology</subject><issn>1936-2625</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNpVUMtOwzAQtJAQLYVfQDlyiXDs2E4uSFCVglqpOZSz5fhBjRwnxEkFf48ryktaaXdnVzOzewKmWYlpiigiE3AewiuENEM5PAMTRAiBBcmmoFq8d70OwbY-aU1S3a9utptqlVifSN3vrRQukcLHOhFe_WLWD73QnR122tnYe912TgQrLsCpES7oy2OegeeHxXb-mK43y6f53TrtEKVDSkpTYIkoyxjDRjGCc1MwVhLIaK2goUbi2pTaSMTKQ8iIR_sU0kIqpfAM3H7xdmPdaCX1wZDjXW8b0X_wVlj-f-Ltjr-0e54jBglCkeD6SNC3b6MOA29skNo5EW8ZA89onuXRICVx9eqv1o_I9xvxJ7jwbkk</recordid><startdate>20140101</startdate><enddate>20140101</enddate><creator>Luo, Qiong</creator><creator>Lei, Bin</creator><creator>Liu, Shuguang</creator><creator>Chen, Yaowen</creator><creator>Sheng, Wenjie</creator><creator>Lin, Peixin</creator><creator>Li, Wenxia</creator><creator>Zhu, Haili</creator><creator>Shen, Hong</creator><general>e-Century Publishing Corporation</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20140101</creationdate><title>Expression of PBK/TOPK in cervical cancer and cervical intraepithelial neoplasia</title><author>Luo, Qiong ; Lei, Bin ; Liu, Shuguang ; Chen, Yaowen ; Sheng, Wenjie ; Lin, Peixin ; Li, Wenxia ; Zhu, Haili ; Shen, Hong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p266t-59f83c2671773fd7534f87795076bd0f6fc3bf9efc2792792c76b6126068cddd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>Carcinoma, Squamous Cell - metabolism</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Cervical Intraepithelial Neoplasia - metabolism</topic><topic>Cervical Intraepithelial Neoplasia - pathology</topic><topic>Female</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Lymphatic Metastasis - pathology</topic><topic>Middle Aged</topic><topic>Mitogen-Activated Protein Kinase Kinases - metabolism</topic><topic>Neoplasm Grading</topic><topic>Neoplasm Invasiveness - pathology</topic><topic>Neoplasm Staging</topic><topic>Original</topic><topic>Uterine Cervical Neoplasms - metabolism</topic><topic>Uterine Cervical Neoplasms - pathology</topic><toplevel>online_resources</toplevel><creatorcontrib>Luo, Qiong</creatorcontrib><creatorcontrib>Lei, Bin</creatorcontrib><creatorcontrib>Liu, Shuguang</creatorcontrib><creatorcontrib>Chen, Yaowen</creatorcontrib><creatorcontrib>Sheng, Wenjie</creatorcontrib><creatorcontrib>Lin, Peixin</creatorcontrib><creatorcontrib>Li, Wenxia</creatorcontrib><creatorcontrib>Zhu, Haili</creatorcontrib><creatorcontrib>Shen, Hong</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of clinical and experimental pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Luo, Qiong</au><au>Lei, Bin</au><au>Liu, Shuguang</au><au>Chen, Yaowen</au><au>Sheng, Wenjie</au><au>Lin, Peixin</au><au>Li, Wenxia</au><au>Zhu, Haili</au><au>Shen, Hong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression of PBK/TOPK in cervical cancer and cervical intraepithelial neoplasia</atitle><jtitle>International journal of clinical and experimental pathology</jtitle><addtitle>Int J Clin Exp Pathol</addtitle><date>2014-01-01</date><risdate>2014</risdate><volume>7</volume><issue>11</issue><spage>8059</spage><epage>8064</epage><pages>8059-8064</pages><eissn>1936-2625</eissn><abstract>objectives: To evaluate the expression of PBK/TOPK (PDZ-binding kinase/T-LAK cell-originated protein kinase) and its clinical significance in cervical cancer and cervical intraepithelial neoplasia.
PBK/TOPK expression was detected in 28 cases of low-grade cervical intraepithelial neoplasia (CINI), 62 cases of high-grade intraepithelial neoplasia and 80 cases of cervical cancer by immunohistochemistry (IHC). Then, the correlation between PBK/TOPK expression and clinicopathological features was quantitatively analyzed by measuring the positive unit (PU).
PBK/TOPK expression was significantly greater in cervical cancer than that in high-grade intraepithelial neoplasia and CINI (P < 0.05). Meanwhile, PBK/TOPK expression in high-grade intraepithelial neoplasia was significantly higher compared with that in CINI (P < 0.05). In addition, PBK/TOPK expression in cervical cancer significantly correlated with histological type, differentiation, lymph node metastasis, vaginal and cervical invasion, TNM stage and tumor size (P < 0.05).
PBK/TOPK expression is closely associated with cervical cancer and cervical intraepithelial neoplasia, which may be served as a useful target for tumor diagnosis and immunotherapy.</abstract><cop>United States</cop><pub>e-Century Publishing Corporation</pub><pmid>25550851</pmid><tpages>6</tpages></addata></record> |
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| ispartof | International journal of clinical and experimental pathology, 2014-01, Vol.7 (11), p.8059-8064 |
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| language | eng |
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| source | PubMed Central |
| subjects | Adult Biomarkers, Tumor - metabolism Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - pathology Cervical Intraepithelial Neoplasia - metabolism Cervical Intraepithelial Neoplasia - pathology Female Humans Immunohistochemistry Lymphatic Metastasis - pathology Middle Aged Mitogen-Activated Protein Kinase Kinases - metabolism Neoplasm Grading Neoplasm Invasiveness - pathology Neoplasm Staging Original Uterine Cervical Neoplasms - metabolism Uterine Cervical Neoplasms - pathology |
| title | Expression of PBK/TOPK in cervical cancer and cervical intraepithelial neoplasia |
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