Natural history of chronic myelomonocytic leukemia: gene sequencing identifies multiple clonal molecular abnormalities associated with rapid progression to acute myeloid leukemia

Key Clinical Message Gene panel sequencing in a CMML patient without any detectable genetic abnormality by conventional genetic studies identified four concurrent somatic mutations in three genes. Gene panel mutation analysis is a rapidly emerging clinical tool to demonstrate the clonality in hemato...

Full description

Saved in:
Bibliographic Details
Published in:Clinical case reports 2014-12, Vol.2 (6), p.265-270
Main Authors: Xiang, Zhifu, Kaur, Varinder, Aburiziq, Ibrahim K., Mehta, Paulette, Emanuel, Peter, Schichman, Steven A.
Format: Article
Language:English
Subjects:
Acute myeloid leukemia
Anemia
Blood
Blood platelets
Bone marrow
Case Reports
chronic myelomonocytic leukemia
clonality
Epigenetics
gene sequencing
Genes
genetic abnormality
Granulocytes
Growth factors
Hematology
Hemoglobin
Laboratories
Leukemia
Mutation
Neutrophils
Tumors
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Key Clinical Message Gene panel sequencing in a CMML patient without any detectable genetic abnormality by conventional genetic studies identified four concurrent somatic mutations in three genes. Gene panel mutation analysis is a rapidly emerging clinical tool to demonstrate the clonality in hematologic malignancies, and to identify the potential targets for therapy. Gene panel sequencing in a CMML patient without any detectable genetic abnormality by conventional genetic studies identified four concurrent somatic mutations in three genes. Gene panel mutation analysis is a rapidly emerging clinical tool to demonstrate the clonality in hematologic malignancies, and to identify the potential targets for therapy.
ISSN:2050-0904
2050-0904
DOI:10.1002/ccr3.110