Complexity of Danger: The Diverse Nature of Damage-associated Molecular Patterns

In reply to internal or external danger stimuli, the body orchestrates an inflammatory response. The endogenous triggers of this process are the damage-associated molecular patterns (DAMPs). DAMPs represent a heterogeneous group of molecules that draw their origin either from inside the various comp...

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Bibliographic Details
Published in:The Journal of biological chemistry 2014-12, Vol.289 (51), p.35237-35245
Main Author: Schaefer, Liliana
Format: Article
Language:English
Subjects:
Animals
ATP
Autophagy
Biglycan
Cytosol - immunology
Cytosol - metabolism
Decorin
Extracellular Matrix - immunology
Extracellular Matrix - metabolism
Heat Shock Protein (HSP)
Heparan Sulfate
Humans
Hyaluronan
Inflammasome
Inflammasomes - immunology
Inflammasomes - metabolism
Inflammation - immunology
Minireviews
Models, Immunological
Necrosis (Necrotic Death)
Proteoglycans - immunology
Proteoglycans - metabolism
Receptors, Pattern Recognition - immunology
Receptors, Pattern Recognition - metabolism
Signal Transduction - immunology
Small Leucine-rich Proteoglycan (SLRP)
Toll-like Receptor (TLR)
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Summary:In reply to internal or external danger stimuli, the body orchestrates an inflammatory response. The endogenous triggers of this process are the damage-associated molecular patterns (DAMPs). DAMPs represent a heterogeneous group of molecules that draw their origin either from inside the various compartments of the cell or from the extracellular space. Following interaction with pattern recognition receptors in cross-talk with various non-immune receptors, DAMPs determine the downstream signaling outcome of septic and aseptic inflammatory responses. In this review, the diverse nature, structural characteristics, and signaling pathways elicited by DAMPs will be critically evaluated.
ISSN:0021-9258
1083-351X
DOI:10.1074/jbc.R114.619304