Procalcitonin and intestinal ischemia:A review of the literature

Intestinal ischemia is common after emergency gastrointestinal or cardiovascular surgery.At present,there are no diagnostic tools for the early diagnosis of intestinal ischemia.In the last decade,procalcitonin(PCT)has been suggested as a marker of this condition.Here,we review the use of PCT as a di...

Full description

Saved in:
Bibliographic Details
Published in:World journal of gastroenterology : WJG 2014-12, Vol.20 (47), p.17773-17778
Main Authors: Cosse, Cyril, Sabbagh, Charles, Kamel, Saïd, Galmiche, Antoine, Regimbeau, Jean-Marc
Format: Article
Language:English
Subjects:
Animals
Area Under Curve
Biomarkers - blood
Calcitonin - blood
Calcitonin Gene-Related Peptide
Diagnosis
Humans
Intestinal
Intestines - blood supply
Intestines - metabolism
Intestines - physiopathology
Ischemia
Ischemia - blood
Ischemia - diagnosis
Ischemia - etiology
Ischemia - physiopathology
Predictive Value of Tests
Procalcitonin
Prognosis
Protein Precursors - blood
Review
Risk Factors
Signal Transduction
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Intestinal ischemia is common after emergency gastrointestinal or cardiovascular surgery.At present,there are no diagnostic tools for the early diagnosis of intestinal ischemia.In the last decade,procalcitonin(PCT)has been suggested as a marker of this condition.Here,we review the use of PCT as a diagnostic tool for intestinal ischemia.Two reviewers independently searched the Pub Med and EMBASE databases for articles on intestinal ischemia and PCT.They then considered(1)the criteria applicable to preclinical and clinicaldata;and(2)PCT’s predictive value in the diagnosis of intestinal ischemia.Article quality was rated according to the STAndards for Reporting of Diagnostic accuracy.Between 1993 and 2014,seven studies(including two preclinical studies and five clinical studies)dealt with the use of PCT to diagnose intestinal ischemia.Procalcitonin’s sensitivity,specificity,positive predictive value and negative predictive value ranged between 72%and 100%;68%and 91%;27%and 90%and 81%and 100%,respectively.The area under the receiver operating characteristic curve ranged from 0.77 to 0.92.In view of the preclinical and clinical data,we consider that PCT can be used in daily practice as a tool for diagnosing intestinal ischemia.
ISSN:1007-9327
2219-2840
DOI:10.3748/wjg.v20.i47.17773