Pharmacological induction of the 70-kDa heat shock protein protects against brain injury

Highlights • We evaluate HSP70-inducer 17-AAG as therapy for traumatic brain injury. • We compare outcomes in a mouse TBI model using two treatment paradigms. • Treated TBI mice show increased HSP70 expression and improved outcomes. • We show that peripherally administered 17-AAG can induce HSP70 in...

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Bibliographic Details
Published in:Neuroscience 2015-01, Vol.284, p.912-919
Main Authors: Kim, N, Kim, J.Y, Yenari, M.A
Format: Article
Language:English
Subjects:
animal studies
Animals
Astrocytes - drug effects
Astrocytes - metabolism
Astrocytes - pathology
Benzoquinones - administration & dosage
Brain - drug effects
Brain - metabolism
Brain - pathology
Brain Hemorrhage, Traumatic - drug therapy
Brain Hemorrhage, Traumatic - metabolism
Brain Hemorrhage, Traumatic - pathology
Brain Injuries - drug therapy
Brain Injuries - metabolism
Brain Injuries - pathology
Disease Models, Animal
HSP70 Heat-Shock Proteins - metabolism
Lactams, Macrocyclic - administration & dosage
Male
Mice, Inbred C57BL
Microglia - drug effects
Microglia - metabolism
Microglia - pathology
Neurology
Neurons - drug effects
Neurons - metabolism
Neurons - pathology
Neuroprotective Agents - administration & dosage
therapeutic approaches
Time Factors
traumatic brain injury
Treatment Outcome
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Summary:Highlights • We evaluate HSP70-inducer 17-AAG as therapy for traumatic brain injury. • We compare outcomes in a mouse TBI model using two treatment paradigms. • Treated TBI mice show increased HSP70 expression and improved outcomes. • We show that peripherally administered 17-AAG can induce HSP70 in the brain. • Pharmacologic HSP70-induction may be a promising, noninvasive intervention for TBI.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2014.11.010