Effect of the protein corona on nanoparticles for modulating cytotoxicity and immunotoxicity

Although the cytotoxicity of nanoparticles (NPs) is greatly influenced by their interactions with blood proteins, toxic effects resulting from blood interactions are often ignored in the development and use of nanostructured biomaterials for in vivo applications. Protein coronas created during the i...

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Bibliographic Details
Published in:International journal of nanomedicine 2015-01, Vol.10, p.97-113
Main Authors: Lee, Yeon Kyung, Choi, Eun-Ju, Webster, Thomas J, Kim, Sang-Hyun, Khang, Dongwoo
Format: Article
Language:English
Subjects:
Adsorption
Binding sites
Biomedical materials
Blood Proteins - metabolism
blood response
Cell Line, Tumor
Cell Survival - drug effects
cytotoxicity
Drug Delivery Systems
Human Umbilical Vein Endothelial Cells
Humans
Hydroxyapatite
Immune system
Immunity, Active - drug effects
immunotoxicity
Medicine
Nanomaterials
Nanoparticles
Nanoparticles - chemistry
nanostructured biomaterials
Properties
protein corona
Protein Corona - chemistry
Proteins
Quantum dots
Review
Studies
Surface Properties
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Summary:Although the cytotoxicity of nanoparticles (NPs) is greatly influenced by their interactions with blood proteins, toxic effects resulting from blood interactions are often ignored in the development and use of nanostructured biomaterials for in vivo applications. Protein coronas created during the initial reaction with NPs can determine the subsequent immunological cascade, and protein coronas formed on NPs can either stimulate or mitigate the immune response. Along these lines, the understanding of NP-protein corona formation in terms of physiochemical surface properties of the NPs and NP interactions with the immune system components in blood is an essential step for evaluating NP toxicity for in vivo therapeutics. This article reviews the most recent developments in NP-based protein coronas through the modification of NP surface properties and discusses the associated immune responses.
ISSN:1178-2013
1176-9114
1178-2013
DOI:10.2147/IJN.S72998