Modified simultaneous integrated boost radiotherapy for an unresectable huge refractory pelvic tumor diagnosed as a rectal adenocarcinoma

A clinical trial of radiotherapy with modified simultaneous integrated boost(SIB)technique against huge tumors was conducted.A 58-year-old male patient who had a huge pelvic tumor diagnosed as a rectal adenocarcinoma due to familial adenomatous polyposis was enrolled in this trial.The total dose of...

Full description

Saved in:
Bibliographic Details
Published in:World journal of gastroenterology : WJG 2014-12, Vol.20 (48), p.18480-18486
Main Authors: Nomiya, Takuma, Akamatsu, Hiroko, Harada, Mayumi, Ota, Ibuki, Hagiwara, Yasuhito, Ichikawa, Mayumi, Miwa, Misako, Kawashiro, Shouhei, Hagiwara, Motohisa, Chin, Masahiro, Hashizume, Eiji, Nemoto, Kenji
Format: Article
Language:English
Subjects:
Adenocarcinoma - pathology
Adenocarcinoma - radiotherapy
Case Report
Clinical
Dose Fractionation
Fatal Outcome
Humans
Image-guided
Male
Middle Aged
Neoplasm Recurrence, Local
Pelvic Neoplasms - pathology
Pelvic Neoplasms - radiotherapy
radiotherapy
Radiotherapy, Computer-Assisted - methods
Rectal
Rectal Neoplasms - pathology
Rectal Neoplasms - radiotherapy
Time Factors
Tomography, X-Ray Computed
Treatment Outcome
trial
Tumor Burden
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A clinical trial of radiotherapy with modified simultaneous integrated boost(SIB)technique against huge tumors was conducted.A 58-year-old male patient who had a huge pelvic tumor diagnosed as a rectal adenocarcinoma due to familial adenomatous polyposis was enrolled in this trial.The total dose of 77 Gy(equivalent dose in 2Gy/fraction)and 64.5 Gy was delivered to the center of the tumor and the surrounding area respectively,andapproximately 20%dose escalation was achieved with the modified SIB technique.The tumor with an initial maximum size of 15 cm disappeared 120 d after the start of the radiotherapy.Performance status of the patient improved from 4 to 0.Radiotherapy with modified SIB may be effective for patients with a huge tumor in terms of tumor shrinkage/disappearance,improvement of QOL,and prolongation of survival.
ISSN:1007-9327
2219-2840
DOI:10.3748/wjg.v20.i48.18480