Current Advances in Polymer-Based Nanotheranostics for Cancer Treatment and Diagnosis

Nanotheranostics is a relatively new, fast-growing field that combines the advantages of treatment and diagnosis via a single nanoscale carrier. The ability to bundle both therapeutic and diagnostic capabilities into one package offers exciting prospects for the development of novel nanomedicine. Na...

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Bibliographic Details
Published in:ACS applied materials & interfaces 2014-12, Vol.6 (24), p.21859-21873
Main Authors: Luk, Brian T, Zhang, Liangfang
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents - administration & dosage
Drug Carriers
Magnetic Resonance Imaging
Mice
Nanotechnology
Neoplasms - diagnosis
Neoplasms - therapy
Polymers - chemistry
Review
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Summary:Nanotheranostics is a relatively new, fast-growing field that combines the advantages of treatment and diagnosis via a single nanoscale carrier. The ability to bundle both therapeutic and diagnostic capabilities into one package offers exciting prospects for the development of novel nanomedicine. Nanotheranostics can deliver treatment while simultaneously monitoring therapy response in real-time, thereby decreasing the potential of over- or under-dosing patients. Polymer-based nanomaterials, in particular, have been used extensively as carriers for both therapeutic and bioimaging agents and thus hold great promise for the construction of multifunctional theranostic formulations. Herein, we review recent advances in polymer-based systems for nanotheranostics, with a particular focus on their applications in cancer research. We summarize the use of polymer nanomaterials for drug delivery, gene delivery, and photodynamic therapy, combined with imaging agents for magnetic resonance imaging, radionuclide imaging, and fluorescence imaging.
ISSN:1944-8244
1944-8252
DOI:10.1021/am5036225