Liposomal Spherical Nucleic Acids

A novel class of metal-free spherical nucleic acid nanostructures was synthesized from readily available starting components. These particles consist of 30 nm liposomal cores, composed of an FDA-approved 1,2-dioleoyl-sn-glycero-3-phospho­choline (DOPC) lipid monomer. The surface of the liposomes was...

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Bibliographic Details
Published in:Journal of the American Chemical Society 2014-07, Vol.136 (28), p.9866-9869
Main Authors: Banga, Resham J, Chernyak, Natalia, Narayan, Suguna P, Nguyen, SonBinh T, Mirkin, Chad A
Format: Article
Language:English
Subjects:
Cell Line
Communication
DNA
DNA - chemistry
Gene Expression Regulation
genes
hydrophobic bonding
Intercalating Agents
Lipid Bilayers
Liposomes - chemistry
nanomaterials
Nucleic Acids - chemistry
Phosphatidylcholines - chemistry
phospholipids
Tocopherols - chemistry
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Summary:A novel class of metal-free spherical nucleic acid nanostructures was synthesized from readily available starting components. These particles consist of 30 nm liposomal cores, composed of an FDA-approved 1,2-dioleoyl-sn-glycero-3-phospho­choline (DOPC) lipid monomer. The surface of the liposomes was functionalized with DNA strands modified with a toco­pherol tail that intercalates into the phospho­lipid layer of the liposomal core via hydrophobic interactions. The spherical nucleic acid architecture not only stabilizes these constructs but also facilitates cellular internalization and gene regulation in SKOV-3 cells.
ISSN:0002-7863
1520-5126
1520-5126
DOI:10.1021/ja504845f