Reduction of facial pigmentation of melasma by topical lignin peroxidase: A novel fast-acting skin-lightening agent

The aim of the present study was to evaluate the efficacy and safety of lignin peroxidase (LIP) as a skin-lightening agent in patients with melasma. A self-controlled clinical study was performed in 31 women who had melasma on both sides of the face. This study involved 8 weeks of a full-face produc...

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Bibliographic Details
Published in:Experimental and therapeutic medicine 2015-02, Vol.9 (2), p.341-344
Main Authors: ZHONG, SHAO-MIN, SUN, NAN, LIU, HUI-XIAN, NIU, YUE-QING, WU, YAN
Format: Article
Language:English
Subjects:
Dermatologic agents
Dermatology
Drug therapy
emulsions
Enzymes
Formulae, receipts, prescriptions
Fungi
Genetic aspects
Health aspects
Hormone replacement therapy
Lignin
lignin peroxidase
melanin
Melanosis
melasma
Patients
Peroxidase
Physiological aspects
Risk factors
skin lightening
Statistical analysis
statistics
Sunscreen
Variance analysis
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Summary:The aim of the present study was to evaluate the efficacy and safety of lignin peroxidase (LIP) as a skin-lightening agent in patients with melasma. A self-controlled clinical study was performed in 31 women who had melasma on both sides of the face. This study involved 8 weeks of a full-face product treatment. The skin color was measured at days 0, 7, 28 and 56 using a chromameter on the forehead and cheeks. Standardized digital photographic images of each side of the face of all subjects were captured by a complexion analysis system. Clinical scores of the pigmentation were determined by two dermatologists. After using the LIP whitening lotion for 7 days, the luminance (L*) values of the melasma and the normal skin were significantly increased from baseline. The L* values continued to increase at days 28 and 56. The melasma area severity index (MASI) score was statistically decreased after 28 days of treatment. No treatment-related adverse events were observed. LIP whitening lotion was able to eliminate the skin pigmentation after 7 days of treatment, and provides a completely innovative approach to rapid skin lightening. The LIP whitening lotion exhibited good compatibility and was well tolerated.
ISSN:1792-0981
1792-1015
DOI:10.3892/etm.2014.2118