Rutin alleviates diabetic cardiomyopathy in a rat model of type 2 diabetes

Diabetic cardiomyopathy (DCM), an independent coronary heart disease that develops in diabetic individuals, is characterized by changes in the myocardial structure and function. The aim of the present study was to investigate the protective effect of rutin on DCM in a streptozotocin-induced diabetic...

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Published in:Experimental and therapeutic medicine 2015-02, Vol.9 (2), p.451-455
Main Authors: WANG, YONG-BIN, GE, ZHI-MING, KANG, WEI-QIANG, LIAN, ZHE-XUN, YAO, JIAN, ZHOU, CHANG-YONG
Format: Article
Language:English
Subjects:
Antioxidants
Apoptosis
Biotechnology
Cardiomyopathy
Cardiovascular disease
Care and treatment
Complications and side effects
Coronary vessels
Cytokines
Diabetes
diabetic cardiomyopathy
diabetic rats
Experiments
Glucose
Health aspects
Heart
Heart diseases
Hyperglycemia
Inflammation
Laboratory animals
Lipid peroxidation
Lipids
Medical research
Metabolism
Oxidative stress
Proteins
Risk factors
rutin
streptozocin
Tumor necrosis factor-TNF
Type 2 diabetes
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Summary:Diabetic cardiomyopathy (DCM), an independent coronary heart disease that develops in diabetic individuals, is characterized by changes in the myocardial structure and function. The aim of the present study was to investigate the protective effect of rutin on DCM in a streptozotocin-induced diabetic rat model. Rutin was orally administrated at a dose of 8 mg/kg body weight. Metabolic profiles, myocardial enzymes and oxidative stress were examined by biochemical tests. The expression levels of cellular proteins associated with apoptosis were measured by western blot analysis, while the levels of inflammatory factors were assessed by immunohistochemical analyses. Rats with DCM exhibited an abnormal metabolic profile, aberrant myocardial enzymes, elevation of oxidative stress markers, increased levels of inflammatory factors and enhanced apoptotic cell death. Notably, rutin was shown to protect and improve myocardial dysfunction, oxidative stress, apoptosis and inflammation in the hearts of the diabetic rats. In conclusion, these results indicated that rutin may have great therapeutic potential in the treatment of DCM, and possibly other cardiovascular disorders, by preventing oxidative stress, inflammation and cell death. However, further detailed studies are required to reveal the exact mechanisms underlying the protective effect of rutin.
ISSN:1792-0981
1792-1015
DOI:10.3892/etm.2014.2090