Basic Mechanisms of Mitral Regurgitation

Abstract Any structural or functional impairment of the mitral valve (MV) apparatus that exhausts MV tissue redundancy available for leaflet coaptation will result in mitral regurgitation (MR). The mechanism responsible for MV malcoaptation and MR can be dysfunction or structural change of the left...

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Bibliographic Details
Published in:Canadian journal of cardiology 2014-09, Vol.30 (9), p.971-981
Main Authors: Dal-Bianco, Jacob P., MD, Beaudoin, Jonathan, MD, Handschumacher, Mark D., BSc, Levine, Robert A., MD
Format: Article
Language:English
Subjects:
Cardiovascular
Chordae Tendineae - pathology
Humans
Mitral Valve - physiopathology
Mitral Valve Insufficiency - etiology
Mitral Valve Insufficiency - physiopathology
Mitral Valve Insufficiency - surgery
Mitral Valve Prolapse - physiopathology
Mitral Valve Prolapse - surgery
Rupture
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Summary:Abstract Any structural or functional impairment of the mitral valve (MV) apparatus that exhausts MV tissue redundancy available for leaflet coaptation will result in mitral regurgitation (MR). The mechanism responsible for MV malcoaptation and MR can be dysfunction or structural change of the left ventricle, the papillary muscles, the chordae tendineae, the mitral annulus, and the MV leaflets. The rationale for MV treatment depends on the MR mechanism and therefore it is essential to identify and understand normal and abnormal MV and MV apparatus function.
ISSN:0828-282X
1916-7075
DOI:10.1016/j.cjca.2014.06.022