Heterotypic gap junctions at glutamatergic mixed synapses are abundant in goldfish brain

Highlights • Immunocytochemical labeling reveals that neuronal gap junctions are abundant and widely distributed in goldfish brain. • Cx35/Cx34.7-containing gap junctions occur primarily at glutamatergic axon terminals, forming excitatory “mixed” synapses. • Immunogold labeling for Cx35 was only in...

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Bibliographic Details
Published in:Neuroscience 2015-01, Vol.285, p.166-193
Main Authors: Rash, J.E, Kamasawa, N, Vanderpool, K.G, Yasumura, T, O’Brien, J, Nannapaneni, S, Pereda, A.E, Nagy, J.I
Format: Article
Language:English
Subjects:
Animals
Axons - metabolism
Brain - metabolism
Carassius auratus
Chordata
connexin34.7
connexin35
Dendrites - metabolism
Fish Proteins - metabolism
freeze-fracture replica immunogold labeling (FRIL)
gap junctions
Gap Junctions - metabolism
Glutamic Acid - metabolism
Goldfish - metabolism
immunofluorescence microscopy
Immunohistochemistry
Microscopy, Confocal
Microscopy, Electron
Neurology
Synapses - metabolism
Teleostei
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Summary:Highlights • Immunocytochemical labeling reveals that neuronal gap junctions are abundant and widely distributed in goldfish brain. • Cx35/Cx34.7-containing gap junctions occur primarily at glutamatergic axon terminals, forming excitatory “mixed” synapses. • Immunogold labeling for Cx35 was only in axon terminal hemiplaques and for Cx34.7 only in somatic and dendritic hemiplaques. • Widespread Cx35:Cx34.7 heterotypic coupling may imply widespread electrical rectification.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2014.10.057