Correlation between Serum RANTES Levels and the Severity of Parkinson’s Disease

Inflammatory mediators may reflect a role of systemic inflammation in the neurodegenerative process of Parkinson’s disease (PD). Interleukin-6 (IL-6) and chemokine ligand 5 (CCL5), also known as RANTES (regulated on activation, normal T cell expressed and secreted), have been implicated in neurodege...

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Bibliographic Details
Published in:Oxidative medicine and cellular longevity 2014-01, Vol.2014 (2014), p.1-4
Main Authors: Li, Rui, Liu, Peng, Liu, Yue, Li, Xiaoqing, Chong, Li, Tang, Peng, Hou, Chen
Format: Article
Language:English
Subjects:
Age
Aged
Alzheimer's disease
Biomarkers
Chemokine CCL5 - blood
Cytokines
Development and progression
Female
Genetic aspects
Humans
Inflammation
Interleukins
Investigations
Lymphocytes
Male
Measurement
Medical research
Medicine, Experimental
Parkinson Disease - blood
Parkinson Disease - pathology
Parkinson's disease
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Summary:Inflammatory mediators may reflect a role of systemic inflammation in the neurodegenerative process of Parkinson’s disease (PD). Interleukin-6 (IL-6) and chemokine ligand 5 (CCL5), also known as RANTES (regulated on activation, normal T cell expressed and secreted), have been implicated in neurodegenerative diseases including PD. Serum levels of RANTES and IL-6 of 78 consecutive PD patients and age-matched 80 controls were measured. Patients with PD had higher RANTES and IL-6 levels compared with the controls. We found that serum RANTES levels strongly correlated with Hoehn-Yahr score and disease duration in PD patients. This study indicated that patients with PD have an on-going systemic inflammatory profile where the elevated peripheral production of RANTES may play a role in the neurodegenerative process.
ISSN:1942-0900
1942-0994
DOI:10.1155/2014/208408