Correlation between Serum RANTES Levels and the Severity of Parkinson’s Disease

Inflammatory mediators may reflect a role of systemic inflammation in the neurodegenerative process of Parkinson’s disease (PD). Interleukin-6 (IL-6) and chemokine ligand 5 (CCL5), also known as RANTES (regulated on activation, normal T cell expressed and secreted), have been implicated in neurodege...

Full description

Saved in:
Bibliographic Details
Published in:Oxidative medicine and cellular longevity 2014-01, Vol.2014 (2014), p.1-4
Main Authors: Li, Rui, Liu, Peng, Liu, Yue, Li, Xiaoqing, Chong, Li, Tang, Peng, Hou, Chen
Format: Article
Language:English
Subjects:
Age
Aged
Alzheimer's disease
Biomarkers
Chemokine CCL5 - blood
Cytokines
Development and progression
Female
Genetic aspects
Humans
Inflammation
Interleukins
Investigations
Lymphocytes
Male
Measurement
Medical research
Medicine, Experimental
Parkinson Disease - blood
Parkinson Disease - pathology
Parkinson's disease
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c523t-c176ab498649a70c19ad93a745b8a6d109a5b8d1ad469d828cacb37eaa4375d3
cites cdi_FETCH-LOGICAL-c523t-c176ab498649a70c19ad93a745b8a6d109a5b8d1ad469d828cacb37eaa4375d3
container_end_page 4
container_issue 2014
container_start_page 1
container_title Oxidative medicine and cellular longevity
container_volume 2014
creator Li, Rui
Liu, Peng
Liu, Yue
Li, Xiaoqing
Chong, Li
Tang, Peng
Hou, Chen
description Inflammatory mediators may reflect a role of systemic inflammation in the neurodegenerative process of Parkinson’s disease (PD). Interleukin-6 (IL-6) and chemokine ligand 5 (CCL5), also known as RANTES (regulated on activation, normal T cell expressed and secreted), have been implicated in neurodegenerative diseases including PD. Serum levels of RANTES and IL-6 of 78 consecutive PD patients and age-matched 80 controls were measured. Patients with PD had higher RANTES and IL-6 levels compared with the controls. We found that serum RANTES levels strongly correlated with Hoehn-Yahr score and disease duration in PD patients. This study indicated that patients with PD have an on-going systemic inflammatory profile where the elevated peripheral production of RANTES may play a role in the neurodegenerative process.
doi_str_mv 10.1155/2014/208408
format article
fullrecord <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4283268</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A417105544</galeid><sourcerecordid>A417105544</sourcerecordid><originalsourceid>FETCH-LOGICAL-c523t-c176ab498649a70c19ad93a745b8a6d109a5b8d1ad469d828cacb37eaa4375d3</originalsourceid><addsrcrecordid>eNqNkctuEzEUhkcIRC-wYo9GYoNaBWyPr5tKUVouUsSt2VtnZs40LhO72DOpuutr8Hp9EhylRIUFYmMf6Xz6fI7_onhByRtKhXjLCOX50JzoR8U-NZxNiDH88a4mZK84SOmSEFkxTp8We0wIrSql94uvsxAj9jC44Msah2tEX55jHFflt-mnxdl5Occ19qkE35bDEnNvjdENN2Xoyi8Qvzufgr-7_ZnKU5cQEj4rnnTQJ3x-fx8Wi3dni9mHyfzz-4-z6XzSCFYNk4YqCTU3WnIDijTUQGsqUFzUGmRLiYFctRRaLk2rmW6gqSuFALxSoq0Oi5Ot9mqsV9g26IcIvb2KbgXxxgZw9s-Od0t7EdaWM10xqbPg9b0ghh8jpsGuXGqw78FjGJOlMs-pNSMio6_-Qi_DGH3ezlJFDJd6I91RF9Cjdb4L-d1mI7VTLjhTJC_1b4oqSoTgPFPHW6qJIaWI3W4xSuwmdbtJ3W5Tz_TLh3-xY3_HnIGjLbB0voVr9382zAh28ADOUUhW_QL7I7wq</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1709468428</pqid></control><display><type>article</type><title>Correlation between Serum RANTES Levels and the Severity of Parkinson’s Disease</title><source>Wiley Online Library Open Access</source><source>Publicly Available Content Database</source><creator>Li, Rui ; Liu, Peng ; Liu, Yue ; Li, Xiaoqing ; Chong, Li ; Tang, Peng ; Hou, Chen</creator><contributor>Dal-Pizzol, Felipe</contributor><creatorcontrib>Li, Rui ; Liu, Peng ; Liu, Yue ; Li, Xiaoqing ; Chong, Li ; Tang, Peng ; Hou, Chen ; Dal-Pizzol, Felipe</creatorcontrib><description>Inflammatory mediators may reflect a role of systemic inflammation in the neurodegenerative process of Parkinson’s disease (PD). Interleukin-6 (IL-6) and chemokine ligand 5 (CCL5), also known as RANTES (regulated on activation, normal T cell expressed and secreted), have been implicated in neurodegenerative diseases including PD. Serum levels of RANTES and IL-6 of 78 consecutive PD patients and age-matched 80 controls were measured. Patients with PD had higher RANTES and IL-6 levels compared with the controls. We found that serum RANTES levels strongly correlated with Hoehn-Yahr score and disease duration in PD patients. This study indicated that patients with PD have an on-going systemic inflammatory profile where the elevated peripheral production of RANTES may play a role in the neurodegenerative process.</description><identifier>ISSN: 1942-0900</identifier><identifier>EISSN: 1942-0994</identifier><identifier>DOI: 10.1155/2014/208408</identifier><identifier>PMID: 25587378</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Age ; Aged ; Alzheimer's disease ; Biomarkers ; Chemokine CCL5 - blood ; Cytokines ; Development and progression ; Female ; Genetic aspects ; Humans ; Inflammation ; Interleukins ; Investigations ; Lymphocytes ; Male ; Measurement ; Medical research ; Medicine, Experimental ; Parkinson Disease - blood ; Parkinson Disease - pathology ; Parkinson's disease</subject><ispartof>Oxidative medicine and cellular longevity, 2014-01, Vol.2014 (2014), p.1-4</ispartof><rights>Copyright © 2014 Peng Tang et al.</rights><rights>COPYRIGHT 2014 John Wiley &amp; Sons, Inc.</rights><rights>COPYRIGHT 2015 John Wiley &amp; Sons, Inc.</rights><rights>Copyright © 2014 Peng Tang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2014 Peng Tang et al. 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c523t-c176ab498649a70c19ad93a745b8a6d109a5b8d1ad469d828cacb37eaa4375d3</citedby><cites>FETCH-LOGICAL-c523t-c176ab498649a70c19ad93a745b8a6d109a5b8d1ad469d828cacb37eaa4375d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/1709468428/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1709468428?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,25753,27924,27925,37012,37013,44590,75126</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25587378$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Dal-Pizzol, Felipe</contributor><creatorcontrib>Li, Rui</creatorcontrib><creatorcontrib>Liu, Peng</creatorcontrib><creatorcontrib>Liu, Yue</creatorcontrib><creatorcontrib>Li, Xiaoqing</creatorcontrib><creatorcontrib>Chong, Li</creatorcontrib><creatorcontrib>Tang, Peng</creatorcontrib><creatorcontrib>Hou, Chen</creatorcontrib><title>Correlation between Serum RANTES Levels and the Severity of Parkinson’s Disease</title><title>Oxidative medicine and cellular longevity</title><addtitle>Oxid Med Cell Longev</addtitle><description>Inflammatory mediators may reflect a role of systemic inflammation in the neurodegenerative process of Parkinson’s disease (PD). Interleukin-6 (IL-6) and chemokine ligand 5 (CCL5), also known as RANTES (regulated on activation, normal T cell expressed and secreted), have been implicated in neurodegenerative diseases including PD. Serum levels of RANTES and IL-6 of 78 consecutive PD patients and age-matched 80 controls were measured. Patients with PD had higher RANTES and IL-6 levels compared with the controls. We found that serum RANTES levels strongly correlated with Hoehn-Yahr score and disease duration in PD patients. This study indicated that patients with PD have an on-going systemic inflammatory profile where the elevated peripheral production of RANTES may play a role in the neurodegenerative process.</description><subject>Age</subject><subject>Aged</subject><subject>Alzheimer's disease</subject><subject>Biomarkers</subject><subject>Chemokine CCL5 - blood</subject><subject>Cytokines</subject><subject>Development and progression</subject><subject>Female</subject><subject>Genetic aspects</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Interleukins</subject><subject>Investigations</subject><subject>Lymphocytes</subject><subject>Male</subject><subject>Measurement</subject><subject>Medical research</subject><subject>Medicine, Experimental</subject><subject>Parkinson Disease - blood</subject><subject>Parkinson Disease - pathology</subject><subject>Parkinson's disease</subject><issn>1942-0900</issn><issn>1942-0994</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><recordid>eNqNkctuEzEUhkcIRC-wYo9GYoNaBWyPr5tKUVouUsSt2VtnZs40LhO72DOpuutr8Hp9EhylRIUFYmMf6Xz6fI7_onhByRtKhXjLCOX50JzoR8U-NZxNiDH88a4mZK84SOmSEFkxTp8We0wIrSql94uvsxAj9jC44Msah2tEX55jHFflt-mnxdl5Occ19qkE35bDEnNvjdENN2Xoyi8Qvzufgr-7_ZnKU5cQEj4rnnTQJ3x-fx8Wi3dni9mHyfzz-4-z6XzSCFYNk4YqCTU3WnIDijTUQGsqUFzUGmRLiYFctRRaLk2rmW6gqSuFALxSoq0Oi5Ot9mqsV9g26IcIvb2KbgXxxgZw9s-Od0t7EdaWM10xqbPg9b0ghh8jpsGuXGqw78FjGJOlMs-pNSMio6_-Qi_DGH3ezlJFDJd6I91RF9Cjdb4L-d1mI7VTLjhTJC_1b4oqSoTgPFPHW6qJIaWI3W4xSuwmdbtJ3W5Tz_TLh3-xY3_HnIGjLbB0voVr9382zAh28ADOUUhW_QL7I7wq</recordid><startdate>20140101</startdate><enddate>20140101</enddate><creator>Li, Rui</creator><creator>Liu, Peng</creator><creator>Liu, Yue</creator><creator>Li, Xiaoqing</creator><creator>Chong, Li</creator><creator>Tang, Peng</creator><creator>Hou, Chen</creator><general>Hindawi Publishing Corporation</general><general>John Wiley &amp; Sons, Inc</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20140101</creationdate><title>Correlation between Serum RANTES Levels and the Severity of Parkinson’s Disease</title><author>Li, Rui ; Liu, Peng ; Liu, Yue ; Li, Xiaoqing ; Chong, Li ; Tang, Peng ; Hou, Chen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c523t-c176ab498649a70c19ad93a745b8a6d109a5b8d1ad469d828cacb37eaa4375d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Age</topic><topic>Aged</topic><topic>Alzheimer's disease</topic><topic>Biomarkers</topic><topic>Chemokine CCL5 - blood</topic><topic>Cytokines</topic><topic>Development and progression</topic><topic>Female</topic><topic>Genetic aspects</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Interleukins</topic><topic>Investigations</topic><topic>Lymphocytes</topic><topic>Male</topic><topic>Measurement</topic><topic>Medical research</topic><topic>Medicine, Experimental</topic><topic>Parkinson Disease - blood</topic><topic>Parkinson Disease - pathology</topic><topic>Parkinson's disease</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Rui</creatorcontrib><creatorcontrib>Liu, Peng</creatorcontrib><creatorcontrib>Liu, Yue</creatorcontrib><creatorcontrib>Li, Xiaoqing</creatorcontrib><creatorcontrib>Chong, Li</creatorcontrib><creatorcontrib>Tang, Peng</creatorcontrib><creatorcontrib>Hou, Chen</creatorcontrib><collection>الدوريات العلمية والإحصائية - e-Marefa Academic and Statistical Periodicals</collection><collection>معرفة - المحتوى العربي الأكاديمي المتكامل - e-Marefa Academic Complete</collection><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Oxidative medicine and cellular longevity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Rui</au><au>Liu, Peng</au><au>Liu, Yue</au><au>Li, Xiaoqing</au><au>Chong, Li</au><au>Tang, Peng</au><au>Hou, Chen</au><au>Dal-Pizzol, Felipe</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Correlation between Serum RANTES Levels and the Severity of Parkinson’s Disease</atitle><jtitle>Oxidative medicine and cellular longevity</jtitle><addtitle>Oxid Med Cell Longev</addtitle><date>2014-01-01</date><risdate>2014</risdate><volume>2014</volume><issue>2014</issue><spage>1</spage><epage>4</epage><pages>1-4</pages><issn>1942-0900</issn><eissn>1942-0994</eissn><abstract>Inflammatory mediators may reflect a role of systemic inflammation in the neurodegenerative process of Parkinson’s disease (PD). Interleukin-6 (IL-6) and chemokine ligand 5 (CCL5), also known as RANTES (regulated on activation, normal T cell expressed and secreted), have been implicated in neurodegenerative diseases including PD. Serum levels of RANTES and IL-6 of 78 consecutive PD patients and age-matched 80 controls were measured. Patients with PD had higher RANTES and IL-6 levels compared with the controls. We found that serum RANTES levels strongly correlated with Hoehn-Yahr score and disease duration in PD patients. This study indicated that patients with PD have an on-going systemic inflammatory profile where the elevated peripheral production of RANTES may play a role in the neurodegenerative process.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>25587378</pmid><doi>10.1155/2014/208408</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1942-0900
ispartof Oxidative medicine and cellular longevity, 2014-01, Vol.2014 (2014), p.1-4
issn 1942-0900
1942-0994
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4283268
source Wiley Online Library Open Access; Publicly Available Content Database
subjects Age
Aged
Alzheimer's disease
Biomarkers
Chemokine CCL5 - blood
Cytokines
Development and progression
Female
Genetic aspects
Humans
Inflammation
Interleukins
Investigations
Lymphocytes
Male
Measurement
Medical research
Medicine, Experimental
Parkinson Disease - blood
Parkinson Disease - pathology
Parkinson's disease
title Correlation between Serum RANTES Levels and the Severity of Parkinson’s Disease
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-06T21%3A22%3A09IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Correlation%20between%20Serum%20RANTES%20Levels%20and%20the%20Severity%20of%20Parkinson%E2%80%99s%20Disease&rft.jtitle=Oxidative%20medicine%20and%20cellular%20longevity&rft.au=Li,%20Rui&rft.date=2014-01-01&rft.volume=2014&rft.issue=2014&rft.spage=1&rft.epage=4&rft.pages=1-4&rft.issn=1942-0900&rft.eissn=1942-0994&rft_id=info:doi/10.1155/2014/208408&rft_dat=%3Cgale_pubme%3EA417105544%3C/gale_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c523t-c176ab498649a70c19ad93a745b8a6d109a5b8d1ad469d828cacb37eaa4375d3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1709468428&rft_id=info:pmid/25587378&rft_galeid=A417105544&rfr_iscdi=true