Sirtuin 1 activator SRT2104 protects Huntington's disease mice

Sirtuin 1 is a nicotinamide adenine dinucleotide‐dependent protein deacetylase which regulates longevity and improves metabolism. Activation of Sirtuin 1 confers beneficial effects in models of neurodegenerative diseases. We and others have provided convincing evidence that overexpression of Sirtuin...

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Bibliographic Details
Published in:Annals of clinical and translational neurology 2014-12, Vol.1 (12), p.1047-1052
Main Authors: Jiang, Mali, Zheng, Jennifer, Peng, Qi, Hou, Zhipeng, Zhang, Jiangyang, Mori, Susumu, Ellis, James L., Vlasuk, George P., Fries, Harvey, Suri, Vipin, Duan, Wenzhen
Format: Article
Language:English
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Summary:Sirtuin 1 is a nicotinamide adenine dinucleotide‐dependent protein deacetylase which regulates longevity and improves metabolism. Activation of Sirtuin 1 confers beneficial effects in models of neurodegenerative diseases. We and others have provided convincing evidence that overexpression of Sirtuin 1 plays a neuroprotective role in mouse models of Huntington's disease. In this study, we report that SRT2104, a small molecule Sirtuin 1 activator, penetrated the blood–brain barrier, attenuated brain atrophy, improved motor function, and extended survival in a mouse model of Huntington's disease. These findings imply a novel therapeutic strategy for Huntington's disease by targeting Sirtuin 1.
ISSN:2328-9503
2328-9503
DOI:10.1002/acn3.135