Fecal microbiota transplantation broadening its application beyond intestinal disorders

Intestinal dysbiosis is now known to be a complication in a myriad of diseases.Fecal microbiota transplantation(FMT),as a microbiota-target therapy,is arguably very effective for curing Clostridium difficile infection and has good outcomes in other intestinal diseases.New insights have raised an int...

Full description

Saved in:
Bibliographic Details
Published in:World journal of gastroenterology : WJG 2015-01, Vol.21 (1), p.102-111
Main Authors: Xu, Meng-Que, Cao, Hai-Long, Wang, Wei-Qiang, Wang, Shan, Cao, Xiao-Cang, Yan, Fang, Wang, Bang-Mao
Format: Article
Language:English
Subjects:
Animals
Biological Therapy - adverse effects
Biological Therapy - methods
Dysbiosis - microbiology
Fecal
Feces - microbiology
Host-Pathogen Interactions
Humans
Intestinal Diseases - diagnosis
Intestinal Diseases - microbiology
Intestinal Diseases - therapy
Intestines - microbiology
microb
Microbiota
Review
transplantation
Intestinal
Treatment Outcome
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Intestinal dysbiosis is now known to be a complication in a myriad of diseases.Fecal microbiota transplantation(FMT),as a microbiota-target therapy,is arguably very effective for curing Clostridium difficile infection and has good outcomes in other intestinal diseases.New insights have raised an interest in FMT for the management of extra-intestinal disorders associated with gut microbiota.This review shows that it is an exciting time in the burgeoning science of FMT application in previously unexpected areas,including metabolic diseases,neuropsychiatric disorders,autoimmune diseases,allergic disorders,and tumors.A randomized controlled trial was conducted on FMT in metabolic syndrome by infusing microbiota from lean donors or from self-collected feces,with the resultant findings showing that the lean donor feces group displayed increased insulin sensitivity,along with increased levels of butyrate-producing intestinal microbiota.Case reports of FMT have also shown favorable outcomes in Parkinson’s disease,multiple sclerosis,myoclonus dystonia,chronic fatigue syndrome,and idiopathic thrombocytopenic purpura.FMT is a promising approach in the manipulation of the intestinal microbiota and has potential applications in a variety of extra-intestinal conditions associated with intestinal dysbiosis.
ISSN:1007-9327
2219-2840
DOI:10.3748/wjg.v21.i1.102