Loading…
Long-Term Follow-Up of Patients with Chronic Chagas Disease and Implantable Cardioverter-Defibrillator
Background/Objectives Chronic Chagas heart disease (ChHD) is associated with ventricular tachyarrhythmias and an increased risk of sudden cardiac death. Little is known about the effectiveness of implantable cardioverter‐defibrillator (ICD) therapy in this population. The objective of this study was...
Saved in:
| Published in: | Pacing and clinical electrophysiology 2014-06, Vol.37 (6), p.751-756 |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c4912-2b1560f979b86b3f3251812b6104af806ad8974b0ccbbf8a08d1ce204da2feec3 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c4912-2b1560f979b86b3f3251812b6104af806ad8974b0ccbbf8a08d1ce204da2feec3 |
| container_end_page | 756 |
| container_issue | 6 |
| container_start_page | 751 |
| container_title | Pacing and clinical electrophysiology |
| container_volume | 37 |
| creator | PEREIRA, FRANCISCA TATIANA MOREIRA ROCHA, EDUARDO ARRAIS MONTEIRO, MARCELO DE PAULA MARTINS NETO, ALMINO CAVALCANTE ROCHA DAHER, ELISABETH DE FRANCESCO SOBRINHO, CARLOS ROBERTO MARTINS RODRIGUES NETO, ROBERTO DA JUSTA PIRES |
| description | Background/Objectives
Chronic Chagas heart disease (ChHD) is associated with ventricular tachyarrhythmias and an increased risk of sudden cardiac death. Little is known about the effectiveness of implantable cardioverter‐defibrillator (ICD) therapy in this population. The objective of this study was to evaluate the efficacy of ICD in patients with ChHD and to identify predictors of mortality and appropriate ICD shocks.
Methods
The cohort study included 65 patients with ChHD and ICD for primary and secondary prevention of sudden death. The Cox model was applied to evaluate the predictors of mortality, and survival was assessed by Kaplan‐Meier analysis.
Results
The median age was 56 ± 11.9 years. The median follow‐up was 40 ± 26.8 months. Among the patients 23 (36.5%) had appropriate shocks. A total of 13 (20%) patients died (6.1% of annual mortality rate), and there was no sudden death. In univariate Cox model, functional class IV (hazard ratio [HR] = 1.99; 95% confidence interval [CI], 1.05–3.76; P = 0.034), primary prevention (HR = 0.29; 95% CI, 0.09–0.99; P = 0.048), lower education (HR = 2.51; 95% CI, 1.05–5.99; P = 0.038), and ejection fraction |
| doi_str_mv | 10.1111/pace.12342 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4285790</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1546213767</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4912-2b1560f979b86b3f3251812b6104af806ad8974b0ccbbf8a08d1ce204da2feec3</originalsourceid><addsrcrecordid>eNqNkUFv0zAYhi0EYqVw4QegHBFShu04iXNBmrKtTFQwiU07Wp-dz60hjYOdruzf49GtggvCl-_g53vl1w8hrxk9Zum8H8HgMeOF4E_IjJWC5pKVzVMyo0zUuSxkc0RexPiNUlpRUT4nR1yIqhZSzohd-mGVX2HYZOe-7_0uvx4zb7NLmBwOU8x2blpn7Tr4wZk0YQUxO3URIWIGQ5ddbMYehgl0j1kLoXP-FsOEIT9F63RwfQ-TDy_JMwt9xFcPc06uz8-u2o_58svioj1Z5kY0jOdcs7KitqkbLStd2IKXTDKuK0YFWEkr6GRTC02N0dpKoLJjBjkVHXCLaIo5-bDPHbd6g51JFQL0agxuA-FOeXDq75vBrdXK3yrBZVk3NAW8fQgI_scW46Q2LhpMLQb026jS91acFXVV_w8qKOU0mZmTd3vUBB9jQHt4EaPq3qG6d6h-O0zwmz87HNBHaQlge2Dnerz7R5S6PGnPHkPz_Y6LE_487ED4rlKVulQ3nxeKff1ULIrFjRLFL86ntw4</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1544002012</pqid></control><display><type>article</type><title>Long-Term Follow-Up of Patients with Chronic Chagas Disease and Implantable Cardioverter-Defibrillator</title><source>Wiley</source><source>SPORTDiscus</source><creator>PEREIRA, FRANCISCA TATIANA MOREIRA ; ROCHA, EDUARDO ARRAIS ; MONTEIRO, MARCELO DE PAULA MARTINS ; NETO, ALMINO CAVALCANTE ROCHA ; DAHER, ELISABETH DE FRANCESCO ; SOBRINHO, CARLOS ROBERTO MARTINS RODRIGUES ; NETO, ROBERTO DA JUSTA PIRES</creator><creatorcontrib>PEREIRA, FRANCISCA TATIANA MOREIRA ; ROCHA, EDUARDO ARRAIS ; MONTEIRO, MARCELO DE PAULA MARTINS ; NETO, ALMINO CAVALCANTE ROCHA ; DAHER, ELISABETH DE FRANCESCO ; SOBRINHO, CARLOS ROBERTO MARTINS RODRIGUES ; NETO, ROBERTO DA JUSTA PIRES</creatorcontrib><description>Background/Objectives
Chronic Chagas heart disease (ChHD) is associated with ventricular tachyarrhythmias and an increased risk of sudden cardiac death. Little is known about the effectiveness of implantable cardioverter‐defibrillator (ICD) therapy in this population. The objective of this study was to evaluate the efficacy of ICD in patients with ChHD and to identify predictors of mortality and appropriate ICD shocks.
Methods
The cohort study included 65 patients with ChHD and ICD for primary and secondary prevention of sudden death. The Cox model was applied to evaluate the predictors of mortality, and survival was assessed by Kaplan‐Meier analysis.
Results
The median age was 56 ± 11.9 years. The median follow‐up was 40 ± 26.8 months. Among the patients 23 (36.5%) had appropriate shocks. A total of 13 (20%) patients died (6.1% of annual mortality rate), and there was no sudden death. In univariate Cox model, functional class IV (hazard ratio [HR] = 1.99; 95% confidence interval [CI], 1.05–3.76; P = 0.034), primary prevention (HR = 0.29; 95% CI, 0.09–0.99; P = 0.048), lower education (HR = 2.51; 95% CI, 1.05–5.99; P = 0.038), and ejection fraction <30% (HR = 2.80; 95% CI, 1.09–7.18; P = 0.032) were predictors of worse prognosis (death). In the multivariate Cox model, an ejection fraction <30% and the low education remained predictors of poor prognosis. Predictors of appropriate shocks were not found.
Conclusions
The ICD was effective for the prevention of sudden cardiac death in patients with chronic ChHD. An ejection fraction <30% and low education were predictors of poor prognosis.</description><identifier>ISSN: 0147-8389</identifier><identifier>EISSN: 1540-8159</identifier><identifier>DOI: 10.1111/pace.12342</identifier><identifier>PMID: 24467488</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Brazil - epidemiology ; Chagas Cardiomyopathy - mortality ; Chagas Cardiomyopathy - therapy ; Chronic Disease ; Cohort Studies ; Comorbidity ; CRT ; Death, Sudden, Cardiac - epidemiology ; Death, Sudden, Cardiac - prevention & control ; defibrillation-ICD ; Defibrillators, Implantable - statistics & numerical data ; Devices ; Female ; Follow-Up Studies ; Humans ; Incidence ; Longitudinal Studies ; Male ; Middle Aged ; Retrospective Studies ; Risk Assessment ; Survival Rate ; Treatment Outcome</subject><ispartof>Pacing and clinical electrophysiology, 2014-06, Vol.37 (6), p.751-756</ispartof><rights>2014, The Authors. published by Wiley Periodicals, Inc.</rights><rights>2014, The Authors. Pacing and Clinical Electrophysiology published by Wiley Periodicals, Inc.</rights><rights>2014, The Authors. published by Wiley Periodicals, Inc. 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4912-2b1560f979b86b3f3251812b6104af806ad8974b0ccbbf8a08d1ce204da2feec3</citedby><cites>FETCH-LOGICAL-c4912-2b1560f979b86b3f3251812b6104af806ad8974b0ccbbf8a08d1ce204da2feec3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24467488$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>PEREIRA, FRANCISCA TATIANA MOREIRA</creatorcontrib><creatorcontrib>ROCHA, EDUARDO ARRAIS</creatorcontrib><creatorcontrib>MONTEIRO, MARCELO DE PAULA MARTINS</creatorcontrib><creatorcontrib>NETO, ALMINO CAVALCANTE ROCHA</creatorcontrib><creatorcontrib>DAHER, ELISABETH DE FRANCESCO</creatorcontrib><creatorcontrib>SOBRINHO, CARLOS ROBERTO MARTINS RODRIGUES</creatorcontrib><creatorcontrib>NETO, ROBERTO DA JUSTA PIRES</creatorcontrib><title>Long-Term Follow-Up of Patients with Chronic Chagas Disease and Implantable Cardioverter-Defibrillator</title><title>Pacing and clinical electrophysiology</title><addtitle>Pacing and Clinical Electrophysiology</addtitle><description>Background/Objectives
Chronic Chagas heart disease (ChHD) is associated with ventricular tachyarrhythmias and an increased risk of sudden cardiac death. Little is known about the effectiveness of implantable cardioverter‐defibrillator (ICD) therapy in this population. The objective of this study was to evaluate the efficacy of ICD in patients with ChHD and to identify predictors of mortality and appropriate ICD shocks.
Methods
The cohort study included 65 patients with ChHD and ICD for primary and secondary prevention of sudden death. The Cox model was applied to evaluate the predictors of mortality, and survival was assessed by Kaplan‐Meier analysis.
Results
The median age was 56 ± 11.9 years. The median follow‐up was 40 ± 26.8 months. Among the patients 23 (36.5%) had appropriate shocks. A total of 13 (20%) patients died (6.1% of annual mortality rate), and there was no sudden death. In univariate Cox model, functional class IV (hazard ratio [HR] = 1.99; 95% confidence interval [CI], 1.05–3.76; P = 0.034), primary prevention (HR = 0.29; 95% CI, 0.09–0.99; P = 0.048), lower education (HR = 2.51; 95% CI, 1.05–5.99; P = 0.038), and ejection fraction <30% (HR = 2.80; 95% CI, 1.09–7.18; P = 0.032) were predictors of worse prognosis (death). In the multivariate Cox model, an ejection fraction <30% and the low education remained predictors of poor prognosis. Predictors of appropriate shocks were not found.
Conclusions
The ICD was effective for the prevention of sudden cardiac death in patients with chronic ChHD. An ejection fraction <30% and low education were predictors of poor prognosis.</description><subject>Brazil - epidemiology</subject><subject>Chagas Cardiomyopathy - mortality</subject><subject>Chagas Cardiomyopathy - therapy</subject><subject>Chronic Disease</subject><subject>Cohort Studies</subject><subject>Comorbidity</subject><subject>CRT</subject><subject>Death, Sudden, Cardiac - epidemiology</subject><subject>Death, Sudden, Cardiac - prevention & control</subject><subject>defibrillation-ICD</subject><subject>Defibrillators, Implantable - statistics & numerical data</subject><subject>Devices</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Incidence</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Retrospective Studies</subject><subject>Risk Assessment</subject><subject>Survival Rate</subject><subject>Treatment Outcome</subject><issn>0147-8389</issn><issn>1540-8159</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><recordid>eNqNkUFv0zAYhi0EYqVw4QegHBFShu04iXNBmrKtTFQwiU07Wp-dz60hjYOdruzf49GtggvCl-_g53vl1w8hrxk9Zum8H8HgMeOF4E_IjJWC5pKVzVMyo0zUuSxkc0RexPiNUlpRUT4nR1yIqhZSzohd-mGVX2HYZOe-7_0uvx4zb7NLmBwOU8x2blpn7Tr4wZk0YQUxO3URIWIGQ5ddbMYehgl0j1kLoXP-FsOEIT9F63RwfQ-TDy_JMwt9xFcPc06uz8-u2o_58svioj1Z5kY0jOdcs7KitqkbLStd2IKXTDKuK0YFWEkr6GRTC02N0dpKoLJjBjkVHXCLaIo5-bDPHbd6g51JFQL0agxuA-FOeXDq75vBrdXK3yrBZVk3NAW8fQgI_scW46Q2LhpMLQb026jS91acFXVV_w8qKOU0mZmTd3vUBB9jQHt4EaPq3qG6d6h-O0zwmz87HNBHaQlge2Dnerz7R5S6PGnPHkPz_Y6LE_487ED4rlKVulQ3nxeKff1ULIrFjRLFL86ntw4</recordid><startdate>201406</startdate><enddate>201406</enddate><creator>PEREIRA, FRANCISCA TATIANA MOREIRA</creator><creator>ROCHA, EDUARDO ARRAIS</creator><creator>MONTEIRO, MARCELO DE PAULA MARTINS</creator><creator>NETO, ALMINO CAVALCANTE ROCHA</creator><creator>DAHER, ELISABETH DE FRANCESCO</creator><creator>SOBRINHO, CARLOS ROBERTO MARTINS RODRIGUES</creator><creator>NETO, ROBERTO DA JUSTA PIRES</creator><general>Blackwell Publishing Ltd</general><general>BlackWell Publishing Ltd</general><scope>BSCLL</scope><scope>24P</scope><scope>WIN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>C1K</scope><scope>F1W</scope><scope>H95</scope><scope>H97</scope><scope>L.G</scope><scope>M7N</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201406</creationdate><title>Long-Term Follow-Up of Patients with Chronic Chagas Disease and Implantable Cardioverter-Defibrillator</title><author>PEREIRA, FRANCISCA TATIANA MOREIRA ; ROCHA, EDUARDO ARRAIS ; MONTEIRO, MARCELO DE PAULA MARTINS ; NETO, ALMINO CAVALCANTE ROCHA ; DAHER, ELISABETH DE FRANCESCO ; SOBRINHO, CARLOS ROBERTO MARTINS RODRIGUES ; NETO, ROBERTO DA JUSTA PIRES</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4912-2b1560f979b86b3f3251812b6104af806ad8974b0ccbbf8a08d1ce204da2feec3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Brazil - epidemiology</topic><topic>Chagas Cardiomyopathy - mortality</topic><topic>Chagas Cardiomyopathy - therapy</topic><topic>Chronic Disease</topic><topic>Cohort Studies</topic><topic>Comorbidity</topic><topic>CRT</topic><topic>Death, Sudden, Cardiac - epidemiology</topic><topic>Death, Sudden, Cardiac - prevention & control</topic><topic>defibrillation-ICD</topic><topic>Defibrillators, Implantable - statistics & numerical data</topic><topic>Devices</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Incidence</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Retrospective Studies</topic><topic>Risk Assessment</topic><topic>Survival Rate</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>PEREIRA, FRANCISCA TATIANA MOREIRA</creatorcontrib><creatorcontrib>ROCHA, EDUARDO ARRAIS</creatorcontrib><creatorcontrib>MONTEIRO, MARCELO DE PAULA MARTINS</creatorcontrib><creatorcontrib>NETO, ALMINO CAVALCANTE ROCHA</creatorcontrib><creatorcontrib>DAHER, ELISABETH DE FRANCESCO</creatorcontrib><creatorcontrib>SOBRINHO, CARLOS ROBERTO MARTINS RODRIGUES</creatorcontrib><creatorcontrib>NETO, ROBERTO DA JUSTA PIRES</creatorcontrib><collection>Istex</collection><collection>Wiley Online Library Journals Open Access</collection><collection>Wiley Online Library Free Content</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Pacing and clinical electrophysiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>PEREIRA, FRANCISCA TATIANA MOREIRA</au><au>ROCHA, EDUARDO ARRAIS</au><au>MONTEIRO, MARCELO DE PAULA MARTINS</au><au>NETO, ALMINO CAVALCANTE ROCHA</au><au>DAHER, ELISABETH DE FRANCESCO</au><au>SOBRINHO, CARLOS ROBERTO MARTINS RODRIGUES</au><au>NETO, ROBERTO DA JUSTA PIRES</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Long-Term Follow-Up of Patients with Chronic Chagas Disease and Implantable Cardioverter-Defibrillator</atitle><jtitle>Pacing and clinical electrophysiology</jtitle><addtitle>Pacing and Clinical Electrophysiology</addtitle><date>2014-06</date><risdate>2014</risdate><volume>37</volume><issue>6</issue><spage>751</spage><epage>756</epage><pages>751-756</pages><issn>0147-8389</issn><eissn>1540-8159</eissn><abstract>Background/Objectives
Chronic Chagas heart disease (ChHD) is associated with ventricular tachyarrhythmias and an increased risk of sudden cardiac death. Little is known about the effectiveness of implantable cardioverter‐defibrillator (ICD) therapy in this population. The objective of this study was to evaluate the efficacy of ICD in patients with ChHD and to identify predictors of mortality and appropriate ICD shocks.
Methods
The cohort study included 65 patients with ChHD and ICD for primary and secondary prevention of sudden death. The Cox model was applied to evaluate the predictors of mortality, and survival was assessed by Kaplan‐Meier analysis.
Results
The median age was 56 ± 11.9 years. The median follow‐up was 40 ± 26.8 months. Among the patients 23 (36.5%) had appropriate shocks. A total of 13 (20%) patients died (6.1% of annual mortality rate), and there was no sudden death. In univariate Cox model, functional class IV (hazard ratio [HR] = 1.99; 95% confidence interval [CI], 1.05–3.76; P = 0.034), primary prevention (HR = 0.29; 95% CI, 0.09–0.99; P = 0.048), lower education (HR = 2.51; 95% CI, 1.05–5.99; P = 0.038), and ejection fraction <30% (HR = 2.80; 95% CI, 1.09–7.18; P = 0.032) were predictors of worse prognosis (death). In the multivariate Cox model, an ejection fraction <30% and the low education remained predictors of poor prognosis. Predictors of appropriate shocks were not found.
Conclusions
The ICD was effective for the prevention of sudden cardiac death in patients with chronic ChHD. An ejection fraction <30% and low education were predictors of poor prognosis.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>24467488</pmid><doi>10.1111/pace.12342</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0147-8389 |
| ispartof | Pacing and clinical electrophysiology, 2014-06, Vol.37 (6), p.751-756 |
| issn | 0147-8389 1540-8159 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4285790 |
| source | Wiley; SPORTDiscus |
| subjects | Brazil - epidemiology Chagas Cardiomyopathy - mortality Chagas Cardiomyopathy - therapy Chronic Disease Cohort Studies Comorbidity CRT Death, Sudden, Cardiac - epidemiology Death, Sudden, Cardiac - prevention & control defibrillation-ICD Defibrillators, Implantable - statistics & numerical data Devices Female Follow-Up Studies Humans Incidence Longitudinal Studies Male Middle Aged Retrospective Studies Risk Assessment Survival Rate Treatment Outcome |
| title | Long-Term Follow-Up of Patients with Chronic Chagas Disease and Implantable Cardioverter-Defibrillator |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-01T20%3A13%3A22IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Long-Term%20Follow-Up%20of%20Patients%20with%20Chronic%20Chagas%20Disease%20and%20Implantable%20Cardioverter-Defibrillator&rft.jtitle=Pacing%20and%20clinical%20electrophysiology&rft.au=PEREIRA,%20FRANCISCA%20TATIANA%20MOREIRA&rft.date=2014-06&rft.volume=37&rft.issue=6&rft.spage=751&rft.epage=756&rft.pages=751-756&rft.issn=0147-8389&rft.eissn=1540-8159&rft_id=info:doi/10.1111/pace.12342&rft_dat=%3Cproquest_pubme%3E1546213767%3C/proquest_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c4912-2b1560f979b86b3f3251812b6104af806ad8974b0ccbbf8a08d1ce204da2feec3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1544002012&rft_id=info:pmid/24467488&rfr_iscdi=true |