Development of benzo[1,4]oxazines as biofilm inhibitors and dispersal agents against Vibrio cholerae † †Electronic supplementary information (ESI) available: Experimental procedures and analytical data along with protocols for all biological experiments. See DOI: 10.1039/c4cc07003h Click here for additional data file

Synthesis of a library of natural product-inspired biofilm inhibitors has revealed a compound with selective and potent anti-biofilm activity against V. cholerae . Bacterial biofilms are estimated to be associated with over 65 percent of all nosocomial infections. However, no therapeutics have been...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2014-12, Vol.51 (7), p.1305-1308
Main Authors: Warner, Christopher J. A., Cheng, Andrew T., Yildiz, Fitnat H., Linington, Roger G.
Format: Article
Language:English
Subjects:
Chemistry
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Summary:Synthesis of a library of natural product-inspired biofilm inhibitors has revealed a compound with selective and potent anti-biofilm activity against V. cholerae . Bacterial biofilms are estimated to be associated with over 65 percent of all nosocomial infections. However, no therapeutics have been approved by the FDA which directly mediate biofilm formation or persistence. Herein we report oxazine 25 as a highly potent inhibitor, disperser and in the presence of the appropriate antibiotic eradicator of V. cholerae biofilms.
ISSN:1359-7345
1364-548X
DOI:10.1039/c4cc07003h