MicroRNAs in breast cancer: oncogene and tumor suppressors with clinical potential

MicroRNAs (miRs) are small single-stranded RNA molecules, which function as key negative regulators of post-transcriptional modulation in almost all biological processes. Abnormal expression of microRNAs has been observed in various types of cancer including breast cancer. Great efforts have been ma...

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Published in:Journal of Zhejiang University. B. Science 2015, Vol.16 (1), p.18-31
Main Authors: Wang, Wei, Luo, Yun-ping
Format: Article
Language:English
Subjects:
Animals
Biomarkers, Tumor - metabolism
Biomedical and Life Sciences
Biomedicine
Breast Neoplasms - blood
Breast Neoplasms - genetics
Breast Neoplasms - metabolism
Female
Gene Expression Profiling
Gene Expression Regulation, Neoplastic
Genes, Tumor Suppressor
Humans
Mammary Neoplasms, Experimental - metabolism
Mice
MicroRNAs - metabolism
Neoplasm Metastasis
Oncogenes
Review
Reviews
RNA Processing, Post-Transcriptional
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container_title Journal of Zhejiang University. B. Science
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creator Wang, Wei
Luo, Yun-ping
description MicroRNAs (miRs) are small single-stranded RNA molecules, which function as key negative regulators of post-transcriptional modulation in almost all biological processes. Abnormal expression of microRNAs has been observed in various types of cancer including breast cancer. Great efforts have been made to identify an association between microRNA expression profiles and breast cancer, and to understand the functional role and molecular mechanism of aberrant-expressed microRNAs. As research progressed, ‘oncogenic microRNAs’ and ‘tumor suppressive microRNAs’ became a focus of interest. The potential of candidate microRNAs from both intercellular (tissue) and extracellular (serum) sources for clinical diagnosis and prognosis was revealed, and treatments involving microRNA achieved some amazing curative effects in cancer disease models. In this review, advances from the most recent studies of microRNAs in one of the most common cancers, breast cancer, are highlighted, especially the functions of specifically selected microRNAs. We also assess the potential value of these microRNAs as diagnostic and prognostic markers, and discuss the possible development of microRNA-based therapies.
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subjects Animals
Biomarkers, Tumor - metabolism
Biomedical and Life Sciences
Biomedicine
Breast Neoplasms - blood
Breast Neoplasms - genetics
Breast Neoplasms - metabolism
Female
Gene Expression Profiling
Gene Expression Regulation, Neoplastic
Genes, Tumor Suppressor
Humans
Mammary Neoplasms, Experimental - metabolism
Mice
MicroRNAs - metabolism
Neoplasm Metastasis
Oncogenes
Review
Reviews
RNA Processing, Post-Transcriptional
title MicroRNAs in breast cancer: oncogene and tumor suppressors with clinical potential
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