Conventional US, elastography and contrast enhanced US features of papillary thyroid microcarcinoma predict central compartment lymph node metastases

Lymph node metastases at the time of diagnosis have a major impact on both therapeutic strategy and tumor recurrence for patients with papillary thyroid microcarcinoma (PTMC). Our objective was to evaluate the usefulness of PTMC characteristics on ultrasonography for predicting central compartment l...

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Bibliographic Details
Published in:Scientific reports 2015-01, Vol.5 (1), p.7748-7748, Article 7748
Main Authors: Hong, Yu-Rong, Yan, Cao-Xin, Mo, Guo-Qaing, Luo, Zhi-Yan, Zhang, Ying, Wang, Yong, Huang, Pin-Tong
Format: Article
Language:English
Subjects:
631/67/2321
692/700/1421/1860
Adolescent
Adult
Aged
Biopsy
Carcinoma, Papillary - diagnostic imaging
Carcinoma, Papillary - pathology
Contrast Media
Demography
Elasticity Imaging Techniques
Female
Humanities and Social Sciences
Humans
Logistic Models
Lymph
Lymph nodes
Lymphatic Metastasis - diagnostic imaging
Lymphatic system
Male
Mastectomy
Metastases
Metastasis
Middle Aged
multidisciplinary
Multivariate Analysis
Prognosis
Science
Surgery
Thyroid
Thyroid gland
Thyroid Gland - diagnostic imaging
Thyroid Gland - pathology
Thyroid Neoplasms - diagnostic imaging
Thyroid Neoplasms - pathology
Ultrasonography, Doppler
Ultrasound
Young Adult
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Summary:Lymph node metastases at the time of diagnosis have a major impact on both therapeutic strategy and tumor recurrence for patients with papillary thyroid microcarcinoma (PTMC). Our objective was to evaluate the usefulness of PTMC characteristics on ultrasonography for predicting central compartment lymph node metastases (CCLNM) of PTMC. One hundred twenty seven patients who underwent surgery for PTMC were enrolled in this study. The relationship between the CCLNM and the characteristics on conventional US, elastographic and contrast enhanced ultrasound (CEUS) were investigated. Univariate analysis indicated that PTMCs with CCLNM were more often nodule irregular shape, microcalcifications, hyperenhancing or isoenhancing parametric maps and peak index ≥1 at preoperative US and CEUS than those without CCLNM ( P < 0.01, 0.05, 0.01 and 0.05 respectively). Multivariate analysis showed that microcalcification (OR:2.378, 95% CI: 1.096–5.158) and hyperenhancement or isoenhancement (OR:2.8, 95% CI: 1.287–6.094) were predictive for the presence of CCLNM. Elastography score was not significantly different between the groups. Our study indicated that preoperative thyroid nodule characteristics on conventional US and CEUS may serve as a useful tool to predict central compartment lymph node metastases in PTMC.
ISSN:2045-2322
2045-2322
DOI:10.1038/srep07748