Soluble Klotho is not independently associated with cardiovascular disease in a population of dialysis patients

Dialysis patients suffer from a high burden of cardiovascular disease (CVD). Partly this is due to progressive deterioration of calcium-phosphate homeostasis. Previous studies suggested that besides FGF-23, low levels of Klotho, a protein linked to aging, might constitute a key factor in this detrim...

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Published in:BMC nephrology 2014-12, Vol.15 (1), p.197-197, Article 197
Main Authors: Buiten, Maurits S, de Bie, Mihály K, Bouma-de Krijger, Annet, van Dam, Bastiaan, Dekker, Friedo W, Jukema, J Wouter, Rabelink, Ton J, Rotmans, Joris I
Format: Article
Language:English
Subjects:
Abdomen
Aged
Biomarkers - blood
Calcium - blood
Cardiology
Cardiovascular disease
Cardiovascular Diseases - blood
Cardiovascular Diseases - complications
Chronic kidney failure
Complications and side effects
Coronary vessels
CT imaging
Female
Fibroblast Growth Factors - blood
Glucuronidase - blood
Humans
Kidney Failure, Chronic - complications
Kidney Failure, Chronic - therapy
Male
Middle Aged
Nephrology
Phosphates - blood
Renal Dialysis
Risk factors
Studies
Ventricular Dysfunction, Left - blood
Ventricular Dysfunction, Left - complications
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Summary:Dialysis patients suffer from a high burden of cardiovascular disease (CVD). Partly this is due to progressive deterioration of calcium-phosphate homeostasis. Previous studies suggested that besides FGF-23, low levels of Klotho, a protein linked to aging, might constitute a key factor in this detrimental relationship. The purpose of the present study was to determine the relationship between serum Klotho (sKlotho) and the presence of CVD in dialysis patients. Plasma levels of sKlotho were measured in a cohort of dialysis patients and related to left ventricular (LV) dysfunction (defined as a LV ejection fraction
ISSN:1471-2369
1471-2369
DOI:10.1186/1471-2369-15-197