Liver inflammation is a risk factor for prediabetes in at-risk latinos with and without hepatitis C infection

Background & Aims Early recognition of prediabetes can lead to timely clinical interventions to prevent type 2 diabetes. Both Latino ethnicity and chronic hepatitis C (HCV) have been identified as diabetic risk factors. We aimed to investigate predictors of impaired fasting glucose (IFG), a comm...

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Published in:Liver international 2015-01, Vol.35 (1), p.101-107
Main Authors: Burman, Blaire E., Bacchetti, Peter, Ayala, Claudia E., Gelman, Nicholas, Melgar, Jennifer, Khalili, Mandana
Format: Article
Language:English
Subjects:
Adult
ALT
Blood Glucose - metabolism
Female
Glucose Tolerance Test
HCV
Hepatitis - complications
Hepatitis C - complications
Hispanic Americans
hispanics
Humans
impaired fasting glucose
insulin resistance
Logistic Models
Male
Middle Aged
Odds Ratio
Prediabetic State - ethnology
Prediabetic State - etiology
Risk Factors
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cited_by cdi_FETCH-LOGICAL-c4536-95e2d1076b9eee5f72d7ab7f2454684c43cbdfea63325a81cf526df5c534c8383
cites cdi_FETCH-LOGICAL-c4536-95e2d1076b9eee5f72d7ab7f2454684c43cbdfea63325a81cf526df5c534c8383
container_end_page 107
container_issue 1
container_start_page 101
container_title Liver international
container_volume 35
creator Burman, Blaire E.
Bacchetti, Peter
Ayala, Claudia E.
Gelman, Nicholas
Melgar, Jennifer
Khalili, Mandana
description Background & Aims Early recognition of prediabetes can lead to timely clinical interventions to prevent type 2 diabetes. Both Latino ethnicity and chronic hepatitis C (HCV) have been identified as diabetic risk factors. We aimed to investigate predictors of impaired fasting glucose (IFG), a common prediabetic state, among Latinos with and without HCV. Methods One hundred Latino adults with no history of diabetes or cirrhosis underwent clinical, laboratory, and metabolic evaluation, including oral glucose tolerance testing (OGTT) and insulin suppression testing to quantify directly measured insulin resistance (IR). Isolated IFG was defined as fasting glucose ≥100 mg/dl and
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Both Latino ethnicity and chronic hepatitis C (HCV) have been identified as diabetic risk factors. We aimed to investigate predictors of impaired fasting glucose (IFG), a common prediabetic state, among Latinos with and without HCV. Methods One hundred Latino adults with no history of diabetes or cirrhosis underwent clinical, laboratory, and metabolic evaluation, including oral glucose tolerance testing (OGTT) and insulin suppression testing to quantify directly measured insulin resistance (IR). Isolated IFG was defined as fasting glucose ≥100 mg/dl and &lt;140 mg/dl at 2 h during normal glucose tolerance during OGTT. Results Overall subject characteristics included median age 44 years, 64% male, 40% HCV‐positive and 32% with isolated IFG. Factors associated with isolated IFG included subject age (OR 2.42 per decade, 95%CI 1.40–3.90, P = 0.001), HCV infection (OR 4.0, 95%CI 1.71–9.72, P = 0.002) and alanine aminotransferase (ALT) (OR 2.35 per doubling, 95%CI 1.46–3.77, P &lt; 0.0001). Multipredictor logistic regression analysis identified ALT (OR 2.05 per doubling, P = 0.005, 95% CI 1.24–3.40) and age (OR 2.20 per 10 years, P = 0.005, 95%CI 1.27–3.80) as factors independently associated with IFG. While HCV was associated with 4‐fold higher odds of IFG, this entire effect was mediated by ALT. Conclusions We found strong evidence that liver inflammation is a risk factor for prediabetes among Latinos with and without HCV. Among HCV‐infected individuals, early antiviral therapy could mitigate the effect of inflammation and represent an important intervention to prevent diabetes in this at‐risk population.</description><identifier>ISSN: 1478-3223</identifier><identifier>EISSN: 1478-3231</identifier><identifier>DOI: 10.1111/liv.12676</identifier><identifier>PMID: 25156890</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Adult ; ALT ; Blood Glucose - metabolism ; Female ; Glucose Tolerance Test ; HCV ; Hepatitis - complications ; Hepatitis C - complications ; Hispanic Americans ; hispanics ; Humans ; impaired fasting glucose ; insulin resistance ; Logistic Models ; Male ; Middle Aged ; Odds Ratio ; Prediabetic State - ethnology ; Prediabetic State - etiology ; Risk Factors</subject><ispartof>Liver international, 2015-01, Vol.35 (1), p.101-107</ispartof><rights>2014 John Wiley &amp; Sons A/S. Published by John Wiley &amp; Sons Ltd</rights><rights>2014 John Wiley &amp; Sons A/S. Published by John Wiley &amp; Sons Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4536-95e2d1076b9eee5f72d7ab7f2454684c43cbdfea63325a81cf526df5c534c8383</citedby><cites>FETCH-LOGICAL-c4536-95e2d1076b9eee5f72d7ab7f2454684c43cbdfea63325a81cf526df5c534c8383</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25156890$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Burman, Blaire E.</creatorcontrib><creatorcontrib>Bacchetti, Peter</creatorcontrib><creatorcontrib>Ayala, Claudia E.</creatorcontrib><creatorcontrib>Gelman, Nicholas</creatorcontrib><creatorcontrib>Melgar, Jennifer</creatorcontrib><creatorcontrib>Khalili, Mandana</creatorcontrib><title>Liver inflammation is a risk factor for prediabetes in at-risk latinos with and without hepatitis C infection</title><title>Liver international</title><addtitle>Liver Int</addtitle><description>Background &amp; Aims Early recognition of prediabetes can lead to timely clinical interventions to prevent type 2 diabetes. Both Latino ethnicity and chronic hepatitis C (HCV) have been identified as diabetic risk factors. We aimed to investigate predictors of impaired fasting glucose (IFG), a common prediabetic state, among Latinos with and without HCV. Methods One hundred Latino adults with no history of diabetes or cirrhosis underwent clinical, laboratory, and metabolic evaluation, including oral glucose tolerance testing (OGTT) and insulin suppression testing to quantify directly measured insulin resistance (IR). Isolated IFG was defined as fasting glucose ≥100 mg/dl and &lt;140 mg/dl at 2 h during normal glucose tolerance during OGTT. Results Overall subject characteristics included median age 44 years, 64% male, 40% HCV‐positive and 32% with isolated IFG. Factors associated with isolated IFG included subject age (OR 2.42 per decade, 95%CI 1.40–3.90, P = 0.001), HCV infection (OR 4.0, 95%CI 1.71–9.72, P = 0.002) and alanine aminotransferase (ALT) (OR 2.35 per doubling, 95%CI 1.46–3.77, P &lt; 0.0001). Multipredictor logistic regression analysis identified ALT (OR 2.05 per doubling, P = 0.005, 95% CI 1.24–3.40) and age (OR 2.20 per 10 years, P = 0.005, 95%CI 1.27–3.80) as factors independently associated with IFG. While HCV was associated with 4‐fold higher odds of IFG, this entire effect was mediated by ALT. Conclusions We found strong evidence that liver inflammation is a risk factor for prediabetes among Latinos with and without HCV. Among HCV‐infected individuals, early antiviral therapy could mitigate the effect of inflammation and represent an important intervention to prevent diabetes in this at‐risk population.</description><subject>Adult</subject><subject>ALT</subject><subject>Blood Glucose - metabolism</subject><subject>Female</subject><subject>Glucose Tolerance Test</subject><subject>HCV</subject><subject>Hepatitis - complications</subject><subject>Hepatitis C - complications</subject><subject>Hispanic Americans</subject><subject>hispanics</subject><subject>Humans</subject><subject>impaired fasting glucose</subject><subject>insulin resistance</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Odds Ratio</subject><subject>Prediabetic State - ethnology</subject><subject>Prediabetic State - etiology</subject><subject>Risk Factors</subject><issn>1478-3223</issn><issn>1478-3231</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNp1kU9vFCEYh0mjsf88-AUMRz1MO8AAMxcTs-q2dtMmRu2RMMyLi50ZtsBu229fdrfd1IMkhDfh-T2Q_BB6R8oTktdp71YnhAop9tABqWRdMMrIq91M2T46jPFvWZKm4eQN2qeccFE35QEaZm4FAbvR9noYdHJ-xC5ijYOLN9hqk3zANu9FgM7pFhLETGOdig3R58joI75zaY712G0Gv0x4Dot8lbJrsraDWauP0Wur-whvn84j9Ovb15-Ts2J2NT2ffJ4VpuJMFA0H2pFSirYBAG4l7aRupaUVr0RdmYqZtrOgBWOU65oYy6noLDecVaZmNTtCn7bexbIdoDMwpqB7tQhu0OFBee3Uvzejm6s_fqUq2mQlz4IPT4Lgb5cQkxpcNND3egS_jIoITlktZEMz-nGLmuBjDGB3z5BSretRuR61qSez71_-a0c-95GB0y1w53p4-L9Jzc5_PyuLbcLFBPe7hA43Skgmubq-nKryy8X3i2mO_WCPjS2rew</recordid><startdate>201501</startdate><enddate>201501</enddate><creator>Burman, Blaire E.</creator><creator>Bacchetti, Peter</creator><creator>Ayala, Claudia E.</creator><creator>Gelman, Nicholas</creator><creator>Melgar, Jennifer</creator><creator>Khalili, Mandana</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201501</creationdate><title>Liver inflammation is a risk factor for prediabetes in at-risk latinos with and without hepatitis C infection</title><author>Burman, Blaire E. ; Bacchetti, Peter ; Ayala, Claudia E. ; Gelman, Nicholas ; Melgar, Jennifer ; Khalili, Mandana</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4536-95e2d1076b9eee5f72d7ab7f2454684c43cbdfea63325a81cf526df5c534c8383</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>ALT</topic><topic>Blood Glucose - metabolism</topic><topic>Female</topic><topic>Glucose Tolerance Test</topic><topic>HCV</topic><topic>Hepatitis - complications</topic><topic>Hepatitis C - complications</topic><topic>Hispanic Americans</topic><topic>hispanics</topic><topic>Humans</topic><topic>impaired fasting glucose</topic><topic>insulin resistance</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Odds Ratio</topic><topic>Prediabetic State - ethnology</topic><topic>Prediabetic State - etiology</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Burman, Blaire E.</creatorcontrib><creatorcontrib>Bacchetti, Peter</creatorcontrib><creatorcontrib>Ayala, Claudia E.</creatorcontrib><creatorcontrib>Gelman, Nicholas</creatorcontrib><creatorcontrib>Melgar, Jennifer</creatorcontrib><creatorcontrib>Khalili, Mandana</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Liver international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Burman, Blaire E.</au><au>Bacchetti, Peter</au><au>Ayala, Claudia E.</au><au>Gelman, Nicholas</au><au>Melgar, Jennifer</au><au>Khalili, Mandana</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Liver inflammation is a risk factor for prediabetes in at-risk latinos with and without hepatitis C infection</atitle><jtitle>Liver international</jtitle><addtitle>Liver Int</addtitle><date>2015-01</date><risdate>2015</risdate><volume>35</volume><issue>1</issue><spage>101</spage><epage>107</epage><pages>101-107</pages><issn>1478-3223</issn><eissn>1478-3231</eissn><abstract>Background &amp; Aims Early recognition of prediabetes can lead to timely clinical interventions to prevent type 2 diabetes. Both Latino ethnicity and chronic hepatitis C (HCV) have been identified as diabetic risk factors. We aimed to investigate predictors of impaired fasting glucose (IFG), a common prediabetic state, among Latinos with and without HCV. Methods One hundred Latino adults with no history of diabetes or cirrhosis underwent clinical, laboratory, and metabolic evaluation, including oral glucose tolerance testing (OGTT) and insulin suppression testing to quantify directly measured insulin resistance (IR). Isolated IFG was defined as fasting glucose ≥100 mg/dl and &lt;140 mg/dl at 2 h during normal glucose tolerance during OGTT. Results Overall subject characteristics included median age 44 years, 64% male, 40% HCV‐positive and 32% with isolated IFG. Factors associated with isolated IFG included subject age (OR 2.42 per decade, 95%CI 1.40–3.90, P = 0.001), HCV infection (OR 4.0, 95%CI 1.71–9.72, P = 0.002) and alanine aminotransferase (ALT) (OR 2.35 per doubling, 95%CI 1.46–3.77, P &lt; 0.0001). Multipredictor logistic regression analysis identified ALT (OR 2.05 per doubling, P = 0.005, 95% CI 1.24–3.40) and age (OR 2.20 per 10 years, P = 0.005, 95%CI 1.27–3.80) as factors independently associated with IFG. While HCV was associated with 4‐fold higher odds of IFG, this entire effect was mediated by ALT. Conclusions We found strong evidence that liver inflammation is a risk factor for prediabetes among Latinos with and without HCV. Among HCV‐infected individuals, early antiviral therapy could mitigate the effect of inflammation and represent an important intervention to prevent diabetes in this at‐risk population.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>25156890</pmid><doi>10.1111/liv.12676</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record>
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ispartof Liver international, 2015-01, Vol.35 (1), p.101-107
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source Wiley-Blackwell Read & Publish Collection
subjects Adult
ALT
Blood Glucose - metabolism
Female
Glucose Tolerance Test
HCV
Hepatitis - complications
Hepatitis C - complications
Hispanic Americans
hispanics
Humans
impaired fasting glucose
insulin resistance
Logistic Models
Male
Middle Aged
Odds Ratio
Prediabetic State - ethnology
Prediabetic State - etiology
Risk Factors
title Liver inflammation is a risk factor for prediabetes in at-risk latinos with and without hepatitis C infection
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