Lmo0171, a Novel Internalin-Like Protein, Determines Cell Morphology of Listeria monocytogenes and Its Ability to Invade Human Cell Lines

Internalins comprise a class of Listeria monocytogenes proteins responsible for activation of signalling pathways leading to phagocytic uptake of the bacterium by the host cell. In this paper, a possible role of Lmo0171—a new member of the internalin family was investigated. Disruption of the lmo017...

Full description

Saved in:
Bibliographic Details
Published in:Current microbiology 2015-02, Vol.70 (2), p.267-274
Main Authors: Stachowiak, Radosław, Jagielski, Tomasz, Roeske, Katarzyna, Osińska, Olga, Gunerka, Paweł, Wiśniewski, Jarosław, Bielecki, Jacek
Format: Article
Language:English
Subjects:
adhesion
bacteria
Bacterial Proteins - genetics
Biomedical and Life Sciences
Biotechnology
Cell Line
Cell morphology
Cells
eukaryotic cells
Gene Order
genes
HeLa Cells
human cell lines
Humans
Life Sciences
Listeria
Listeria monocytogenes
Listeria monocytogenes - genetics
Listeria monocytogenes - pathogenicity
Microbiology
Morphology
Mutagenesis
Mutation
Proteins
Virulence - genetics
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Internalins comprise a class of Listeria monocytogenes proteins responsible for activation of signalling pathways leading to phagocytic uptake of the bacterium by the host cell. In this paper, a possible role of Lmo0171—a new member of the internalin family was investigated. Disruption of the lmo0171 gene resulted in important cell morphology alterations along with a decrease in the ability to invade three eukaryotic cell lines, that is Int407, Hep-2 and HeLa and diminished adhesion efficiency to int407, thereby suggesting bifunctionality of the newly characterised Lmo0171 internalin.
ISSN:0343-8651
1432-0991
DOI:10.1007/s00284-014-0715-4