Flavanone glycosides as acetylcholinesterase inhibitors: Computational and experimental evidence

Acetylcholinesterase hydrolyzes the neurotransmitter called acetylcholine and is crucially involved in the regulation of neurotransmission. One of the observable facts in the neurodegenerative disorders like Alzheimer′s disease is the decrease in the level of acetylcholine. Available drugs that are...

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Bibliographic Details
Published in:Indian journal of pharmaceutical sciences 2014-11, Vol.76 (6), p.567-570
Main Authors: Remya, C, Dileep, K, Tintu, I, Variyar, E, Sadasivan, C
Format: Article
Language:English
Subjects:
Acetylcholinesterase
Aging
Alzheimer's disease
Alzheimers disease
Binding sites
Bioflavonoids
Brain research
Enzymes
Flavones
Flavonoids
Health aspects
Hydrogen bonds
Ligands
Memory
Oxidative stress
Physiological aspects
Proteins
Short Communication
Studies
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Summary:Acetylcholinesterase hydrolyzes the neurotransmitter called acetylcholine and is crucially involved in the regulation of neurotransmission. One of the observable facts in the neurodegenerative disorders like Alzheimer′s disease is the decrease in the level of acetylcholine. Available drugs that are used for the treatment of Alzheimer′s disease are primarily acetylcholinesterase inhibitors with multiple activities. They maintain the level of acetylcholine in the brain by inhibiting the acetylcholinesterase function. Hence acetylcholinesterase inhibitors can be used as lead compounds for the development of drugs against AD. In the present study, the binding potential of four flavanone glycosides such as naringin, hesperidin, poncirin and sakuranin against acetylcholinesterase was analysed by using the method of molecular modeling and docking. The activity of the top scored compound, naringin was further investigated by enzyme inhibition studies and its inhibitory concentration (IC 50 ) towards acetylcholinesterase was also determined.
ISSN:0250-474X
1998-3743