Bone marrow stromal cells as immunomodulators. A primer for dermatologists

Abstract Bone marrow stromal cells (BMSCs, also known as mesenchymal stem cells or MSCs) represent a unique cell population in the bone marrow with a long-known function to support hematopoiesis and replace skeletal tissues. The recent discovery that BMSCs also possess potent immunoregulatory featur...

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Bibliographic Details
Published in:Journal of dermatological science 2015-01, Vol.77 (1), p.11-20
Main Authors: Nemeth, Krisztian, Mezey, Eva
Format: Article
Language:English
Subjects:
Animals
Bone Marrow Cells - cytology
Bone Marrow Cells - immunology
Bone marrow stromal cells
Bone Marrow Transplantation
Dermatology
Dermatology - methods
Fibrosis - immunology
Graft vs Host Disease - immunology
Humans
Hypersensitivity - immunology
Immune System - physiology
Immunologic Factors - physiology
Immunomodulation
Inflammatory
Liver - immunology
Lung - immunology
Mesenchymal stem cells
Mice
Skin - immunology
Skin conditions
Skin Diseases - therapy
Skin Physiological Phenomena - immunology
Stem Cells - cytology
Stromal Cells - cytology
Stromal Cells - immunology
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Summary:Abstract Bone marrow stromal cells (BMSCs, also known as mesenchymal stem cells or MSCs) represent a unique cell population in the bone marrow with a long-known function to support hematopoiesis and replace skeletal tissues. The recent discovery that BMSCs also possess potent immunoregulatory features attracted a great deal of attention from stem cell biologists, immunologists and clinicians of different specialties worldwide. Initial clinical experience along with several animal models suggested that intravenously delivered BMSCs are able to regulate a wide variety of host immune cells and act in a way that is beneficial for the recipient in a variety of diseases. The role of the present review is to give a short introduction to the biology of BMSCs and to summarize our current understanding of how BMSCs modulate the immune system with special emphasis on available clinical data. Considering the audience of this journal we will also attempt to guide dermatologists in choosing the right skin conditions where BMSCs might be considered as a therapeutic alternative.
ISSN:0923-1811
1873-569X
DOI:10.1016/j.jdermsci.2014.10.004