Oxidative Stress Associated with Neuronal Apoptosis in Experimental Models of Epilepsy

Epilepsy is considered one of the most common neurological disorders worldwide. Oxidative stress produced by free radicals may play a role in the initiation and progression of epilepsy; the changes in the mitochondrial and the oxidative stress state can lead mechanism associated with neuronal death...

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Bibliographic Details
Published in:Oxidative medicine and cellular longevity 2014-01, Vol.2014 (2014), p.1-12
Main Authors: Rodríguez-Martínez, Erika, Juárez-Rebollar, Daniel, Nava-Ruíz, Concepción, Méndez-Armenta, Marisela, Yescas Gómez, Petra
Format: Article
Language:English
Subjects:
Analysis
Animals
Antioxidants
Apoptosis
Apoptosis - physiology
Disease Models, Animal
Epidemiology
Epilepsy
Epilepsy - genetics
Epilepsy - metabolism
Epilepsy - pathology
Free radicals
Free radicals (Chemistry)
Humans
Mortality
Neurons
Neurons - metabolism
Neurons - pathology
Neurophysiology
Nitrogen dioxide
Oxidative stress
Oxidative Stress - physiology
Reactive Oxygen Species - metabolism
Review
Rodents
Seizures (Medicine)
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Summary:Epilepsy is considered one of the most common neurological disorders worldwide. Oxidative stress produced by free radicals may play a role in the initiation and progression of epilepsy; the changes in the mitochondrial and the oxidative stress state can lead mechanism associated with neuronal death pathway. Bioenergetics state failure and impaired mitochondrial function include excessive free radical production with impaired synthesis of antioxidants. This review summarizes evidence that suggest what is the role of oxidative stress on induction of apoptosis in experimental models of epilepsy.
ISSN:1942-0900
1942-0994
DOI:10.1155/2014/293689