The presence of meniscal lesions is a strong predictor of neuropathic pain in symptomatic knee osteoarthritis: a cross-sectional pilot study

Pain in osteoarthritis (OA) has been classically attributed to joint structural damage. Disparity between the degree of radiographic structural damage and the severity of symptoms implies that factors other than the joint pathology itself contribute to the pain. Peripheral and central sensitization...

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Bibliographic Details
Published in:Arthritis research & therapy 2014-12, Vol.16 (6), p.507-507, Article 507
Main Authors: Roubille, Camille, Raynauld, Jean-Pierre, Abram, François, Paiement, Patrice, Dorais, Marc, Delorme, Philippe, Bessette, Louis, Beaulieu, André D, Martel-Pelletier, Johanne, Pelletier, Jean-Pierre
Format: Article
Language:English
Subjects:
Aged
Cross-Sectional Studies
Diagnosis
Female
Humans
Male
Medical research
Medicine, Experimental
Menisci, Tibial - pathology
Middle Aged
Neuralgia - diagnosis
Neuralgia - etiology
Osteoarthritis
Osteoarthritis, Knee - complications
Osteoarthritis, Knee - diagnosis
Pilot Projects
Predictive Value of Tests
Risk factors
Single-Blind Method
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Summary:Pain in osteoarthritis (OA) has been classically attributed to joint structural damage. Disparity between the degree of radiographic structural damage and the severity of symptoms implies that factors other than the joint pathology itself contribute to the pain. Peripheral and central sensitization have been suggested as two of the underlying mechanisms that contribute to pain in OA. The aim of this study was to explore in symptomatic knee OA patients, the structural changes assessed by magnetic resonance imaging (MRI) that could be used as markers of neuropathic pain (NP). This cross-sectional observational pilot study included 50 knee OA patients with moderate to severe pain (VAS ≥40) in the target knee. The presence of NP was determined based on the PainDETECT questionnaire. Among the 50 patients included, 25 had PainDETECT score ≤12 (unlikely NP), 9 had PainDETECT score between 13 and 18 (uncertain NP) and 16 had PainDETECT score ≥19 (likely NP). WOMAC, PainDETECT, and VAS pain scores as well as knee MRI were assessed. Data showed no significant difference in demographic characteristics between the three groups. However, a positive and statistically significant association was found between the WOMAC pain (P
ISSN:1478-6354
1478-6362
1478-6354
DOI:10.1186/s13075-014-0507-z