Association of cholesteryl ester transfer protein genotypes with paraoxonase‐1 activity, lipid profile and oxidative stress in type 2 diabetes mellitus: A study in San Luis, Argentina

Aims/Introduction Diabetic dyslipidemia is common in type 2 diabetes. The TaqIB polymorphism in cholesteryl ester transfer protein (CETP; B1 and B2 alleles; rs708272) is associated with changes in enzyme activity and lipid concentrations. The aim of the present study was to assess associations of CE...

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Bibliographic Details
Published in:Journal of diabetes investigation 2015-01, Vol.6 (1), p.67-77
Main Authors: Siewert, Susana, Gonzalez, Irma Ines, Lucero, Roberto Osvaldo, Ojeda, Marta Susana
Format: Article
Language:English
Subjects:
Oxidative stress
Polymorphism
Type 2 diabetes mellitus
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Summary:Aims/Introduction Diabetic dyslipidemia is common in type 2 diabetes. The TaqIB polymorphism in cholesteryl ester transfer protein (CETP; B1 and B2 alleles; rs708272) is associated with changes in enzyme activity and lipid concentrations. The aim of the present study was to assess associations of CETP genotypes with lipoprotein profile, oxidant/anti‐oxidant status and the plasma activity of paraoxonase‐1 (PON‐1) in a population of diabetic patients living in San Luis, Argentina. Materials and Methods For oxidative stress status parameters, thiobarbituric acid‐reactive substances (TBARS) and nitric oxide (NO) levels, and catalase and PON‐1 activity were assessed in 40 patients with type 2 diabetes mellitus and 30 healthy participants. CETP polymorphism was analyzed by polymerase chain reaction‐based methods. Results Type 2 diabetes mellitus had significantly higher concentrations of oxidative stress parameters: TBARS (P 
ISSN:2040-1116
2040-1124
DOI:10.1111/jdi.12256