X‑ray-Induced Shortwave Infrared Biomedical Imaging Using Rare-Earth Nanoprobes

Shortwave infrared (SWIR or NIR-II) light provides significant advantages for imaging biological structures due to reduced autofluorescence and photon scattering. Here, we report on the development of rare-earth nanoprobes that exhibit SWIR luminescence following X-ray irradiation. We demonstrate th...

Full description

Saved in:
Bibliographic Details
Published in:Nano letters 2015-01, Vol.15 (1), p.96-102
Main Authors: Naczynski, Dominik Jan, Sun, Conroy, Türkcan, Silvan, Jenkins, Cesare, Koh, Ai Leen, Ikeda, Debra, Pratx, Guillem, Xing, Lei
Format: Article
Language:English
Subjects:
Animals
Contrast Media - chemistry
Contrast Media - pharmacology
Imaging
Infrared
Infrared Rays
Letter
Luminescence
Lymphatic System - anatomy & histology
Metals, Rare Earth - chemistry
Metals, Rare Earth - pharmacology
Mice
Monitors
Nanostructure
Nanostructures - chemistry
Photons
Rare earth metals
Whole Body Imaging
X-Rays
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Shortwave infrared (SWIR or NIR-II) light provides significant advantages for imaging biological structures due to reduced autofluorescence and photon scattering. Here, we report on the development of rare-earth nanoprobes that exhibit SWIR luminescence following X-ray irradiation. We demonstrate the ability of X-ray-induced SWIR luminescence (X-IR) to monitor biodistribution and map lymphatic drainage. Our results indicate X-IR imaging is a promising new modality for preclinical applications and has potential for dual-modality molecular disease imaging.
ISSN:1530-6984
1530-6992
DOI:10.1021/nl504123r