A Case-Control Study Evaluating the Relationship Between Thimerosal-Containing Haemophilus influenzae Type b Vaccine Administration and the Risk for a Pervasive Developmental Disorder Diagnosis in the United States

Thimerosal is an organic mercury (Hg)-containing compound (49.55 % Hg by weight) historically added to many multi-dose vials of vaccine as a preservative. A hypothesis testing case-control study evaluated automated medical records in the Vaccine Safety Datalink (VSD) for organic Hg exposure from Thi...

Full description

Saved in:
Bibliographic Details
Published in:Biological trace element research 2015-02, Vol.163 (1-2), p.28-38
Main Authors: Geier, David A., Kern, Janet K., King, Paul G., Sykes, Lisa K., Geier, Mark R.
Format: Article
Language:English
Subjects:
Age of Onset
Biochemistry
Biomedical and Life Sciences
Biotechnology
Case studies
Case-Control Studies
Child Development Disorders, Pervasive - chemically induced
Child Development Disorders, Pervasive - diagnosis
Child Development Disorders, Pervasive - mortality
Child, Preschool
Developmental disabilities
Drug therapy
Exposure
Female
Haemophilus influenzae
Haemophilus influenzae type b
Haemophilus Vaccines - administration & dosage
Haemophilus Vaccines - adverse effects
Health risk assessment
Humans
Infectious diseases
Influenza
Life Sciences
Male
Mercury
Nutrition
Oncology
Preservatives
Preservatives, Pharmaceutical - administration & dosage
Preservatives, Pharmaceutical - adverse effects
Public health
Seizures, Febrile - chemically induced
Seizures, Febrile - diagnosis
Seizures, Febrile - mortality
Thimerosal - administration & dosage
Thimerosal - adverse effects
Time Factors
United States - epidemiology
Vaccines
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Thimerosal is an organic mercury (Hg)-containing compound (49.55 % Hg by weight) historically added to many multi-dose vials of vaccine as a preservative. A hypothesis testing case-control study evaluated automated medical records in the Vaccine Safety Datalink (VSD) for organic Hg exposure from Thimerosal in Haemophilus influenzae type b (Hib)-containing vaccines administered at specific times within the first 15 months of life among subjects diagnosed with pervasive developmental disorder (PDD) ( n  = 534) in comparison to controls. The generally accepted biologically non-plausible linkage between Thimerosal exposure and subsequent diagnosis of febrile seizure ( n  = 5886) was examined as a control outcome. Cases diagnosed with PDD received significantly more organic Hg within the first 6 months of life (odds ratio (OR) = 1.97, p  
ISSN:0163-4984
1559-0720
DOI:10.1007/s12011-014-0169-3