Test driving ToxCast: endocrine profiling for 1858 chemicals included in phase II

Highlights • 1858 chemicals in EPA's ToxCast program were analyzed for endocrine assay targets. • ToxPi model utilizes 85 in vitro HTS assays and 2 physicochemical properties. • We focused on estrogen, androgen, thyroid, glucocorticoid, PPARs and monoamines. • Many chemicals showing activity in...

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Bibliographic Details
Published in:Current opinion in pharmacology 2014-12, Vol.19, p.145-152
Main Authors: Filer, Dayne, Patisaul, Heather B, Schug, Thaddeus, Reif, David, Thayer, Kristina
Format: Article
Language:English
Subjects:
Animals
Databases, Factual
Endocrine Disruptors - toxicity
High-Throughput Screening Assays
Humans
Internal Medicine
Medical Education
Models, Theoretical
Risk Assessment
United States
United States Environmental Protection Agency
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Summary:Highlights • 1858 chemicals in EPA's ToxCast program were analyzed for endocrine assay targets. • ToxPi model utilizes 85 in vitro HTS assays and 2 physicochemical properties. • We focused on estrogen, androgen, thyroid, glucocorticoid, PPARs and monoamines. • Many chemicals showing activity in the in vitro assays have not been studied for potential endocrine disruption. • Additional research is required to confirm these screening level analyses.
ISSN:1471-4892
1471-4973
DOI:10.1016/j.coph.2014.09.021