Prognostic role of apoptosis-related gene functional variants in advanced non-small-cell lung cancer patients treated with first-line platinum-based chemotherapy

Single-nucleotide polymorphisms in apoptosis-related genes have been shown to play a role in the efficacy of platinum-based chemotherapy and may influence clinical outcomes. Our study aimed to evaluate the correlations of four functional single-nucleotide polymorphisms - FAS -670 A>G, FAS ligand...

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Bibliographic Details
Published in:OncoTargets and therapy 2015-01, Vol.8, p.147-155
Main Authors: Tao, Kai-Yi, Li, Xian-Xing, Xu, Wei-Zhen, Wang, Yin, Zhu, Shuang-Mei, Xie, Hua-Xia, Luo, Wen-Hua, Xu, Yan-Jun, Xu, Xiao-Ling
Format: Article
Language:English
Subjects:
Care and treatment
chemotherapy response
Drug metabolism
Drug therapy
FAS −670 A>G
Genetic aspects
Health aspects
lung cancer
Lung cancer, Non-small cell
Original Research
Platinum compounds
polymorphism
Single nucleotide polymorphisms
survivin 9386 C>T
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Summary:Single-nucleotide polymorphisms in apoptosis-related genes have been shown to play a role in the efficacy of platinum-based chemotherapy and may influence clinical outcomes. Our study aimed to evaluate the correlations of four functional single-nucleotide polymorphisms - FAS -670 A>G, FAS ligand -844 T>C, survivin -31 G>C, and survivin 9386 C>T - with drug response and clinical outcomes in advanced non-small-cell lung cancer patients who received platinum-based chemotherapy. Polymorphisms were evaluated using the polymerase chain reaction-based restriction fragment-length polymorphism technique. Patients with the CC genotype of FAS -670 A>G had worse overall survival (OS) than those with the CT or TT genotype (P=0.044), with median OS values of 20.1 months, 22.8 months, and 26.0 months, respectively. Furthermore, progression-free survival was associated with the FAS -670 A>G polymorphism (P=0.032). In addition, patients with the TC and CC genotypes of survivin 9386 C>T experienced improved survival compared with patients with the TT genotype (median OS 31.4 months and 22.8 months, respectively). The functional FAS -670 A>G and survivin 9386 C>T polymorphisms are potential independent prognostic factors in advanced non-small-cell lung cancer patients treated with platinum-based chemotherapy.
ISSN:1178-6930
1178-6930
DOI:10.2147/OTT.S74855