The use of positron emission tomography/computed tomography imaging in radiation therapy: a phantom study for setting internal target volume of biological target volume

Fluorodeoxyglucose ((18)F-FDG) positron emission tomography/computed tomography (PET/CT) is an important method for detecting tumours, planning radiotherapy treatment, and evaluating treatment responses. However, using the standardized uptake value (SUV) threshold with PET imaging may be suitable no...

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Bibliographic Details
Published in:Radiation oncology (London, England) England), 2015-01, Vol.10 (1), p.1-1, Article 1
Main Authors: Kawakami, Wataru, Takemura, Akihiro, Yokoyama, Kunihiko, Nakajima, Kenichi, Yokoyama, Syoichi, Koshida, Kichiro
Format: Article
Language:English
Subjects:
Abdomen - diagnostic imaging
CT imaging
Fluorodeoxyglucose F18 - pharmacokinetics
Ghosts
Head - diagnostic imaging
Health aspects
Humans
Image processing
Lung - diagnostic imaging
Lung Neoplasms - metabolism
Lung Neoplasms - radiotherapy
Neck - diagnostic imaging
PET imaging
Phantoms, Imaging
Positron-Emission Tomography - methods
Radiation
Radiopharmaceuticals - pharmacokinetics
Radiotherapy
Radiotherapy Planning, Computer-Assisted - methods
Radiotherapy, Intensity-Modulated
Somatotropin
Sport-utility vehicles
Tissue Distribution
Tomography, X-Ray Computed - methods
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Summary:Fluorodeoxyglucose ((18)F-FDG) positron emission tomography/computed tomography (PET/CT) is an important method for detecting tumours, planning radiotherapy treatment, and evaluating treatment responses. However, using the standardized uptake value (SUV) threshold with PET imaging may be suitable not to determine gross tumour volume but to determine biological target volume (BTV). The aim of this study was to extract internal target volume of BTV from PET images. Three spherical densities of (18)F-FDG were employed in a phantom with an air or water background with repetitive motion amplitudes of 0-30 mm. The PET data were reconstructed with attenuation correction (AC) based on CT images obtained by slow CT scanning (SCS) or helical CT scanning (HCS). The errors in measured SUVmax and volumes calculated using SUV threshold values based on SUVmax (THmax) in experiments performed with varying extents of respiratory motion and AC were analysed. A partial volume effect (PVE) was not observed in spheres with diameters of ≥ 28 mm. When calculating SUVmax and THmax, using SCS for AC yielded smaller variance than using HCS (p
ISSN:1748-717X
1748-717X
DOI:10.1186/s13014-014-0315-2