Serum biomarkers reflecting specific tumor tissue remodeling processes are valuable diagnostic tools for lung cancer

Extracellular matrix (ECM) proteins, such as collagen type I and elastin, and intermediate filament (IMF) proteins, such as vimentin are modified and dysregulated as part of the malignant changes leading to disruption of tissue homeostasis. Noninvasive biomarkers that reflect such changes may have a...

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Bibliographic Details
Published in:Cancer medicine (Malden, MA) MA), 2014-10, Vol.3 (5), p.1136-1145
Main Authors: Willumsen, Nicholas, Bager, Cecilie L., Leeming, Diana J., Smith, Victoria, Christiansen, Claus, Karsdal, Morten A., Dornan, David, Bay‐Jensen, Anne‐Christine
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Antigens
Biomarkers
Biomarkers - blood
Cancer Biology
Case-Control Studies
Chronic obstructive pulmonary disease
Citrulline
Collagen (type I)
Elastin
Enzymes
Ethics
Extracellular matrix
Extracellular Matrix Proteins - blood
Extracellular Matrix Proteins - metabolism
Female
Fibrosis
Homeostasis
Humans
Lung cancer
Lung diseases
Lung Neoplasms - blood
Lung Neoplasms - diagnosis
Lung Neoplasms - pathology
Male
Matrix metalloproteinase
Melanoma
Metalloproteinase
Middle Aged
Neoplasm Staging
Obstructive lung disease
Pathology
Patients
Prognosis
Prostate cancer
protein fingerprint
Proteins
Pulmonary fibrosis
remodeling
Risk Factors
Sensitivity and Specificity
serum biomarkers
Studies
tumor tissue
Tumors
Vimentin
Vimentin - blood
Vimentin - metabolism
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Summary:Extracellular matrix (ECM) proteins, such as collagen type I and elastin, and intermediate filament (IMF) proteins, such as vimentin are modified and dysregulated as part of the malignant changes leading to disruption of tissue homeostasis. Noninvasive biomarkers that reflect such changes may have a great potential for cancer. Levels of matrix metalloproteinase (MMP) generated fragments of type I collagen (C1M), of elastin (ELM), and of citrullinated vimentin (VICM) were measured in serum from patients with lung cancer (n = 40), gastrointestinal cancer (n = 25), prostate cancer (n = 14), malignant melanoma (n = 7), chronic obstructive pulmonary disease (COPD) (n = 13), and idiopathic pulmonary fibrosis (IPF) (n = 10), as well as in age‐matched controls (n = 33). The area under the receiver operating characteristics (AUROC) was calculated and a diagnostic decision tree generated from specific cutoff values. C1M and VICM were significantly elevated in lung cancer patients as compared with healthy controls (AUROC = 0.98, P 
ISSN:2045-7634
2045-7634
DOI:10.1002/cam4.303