A simian hemorrhagic fever virus isolate from persistently infected baboons efficiently induces hemorrhagic fever disease in Japanese macaques

Abstract Simian hemorrhagic fever virus is an arterivirus that naturally infects species of African nonhuman primates causing acute or persistent asymptomatic infections. Although it was previously estimated that 1% of baboons are SHFV-positive, more than 10% of wild-caught and captive-bred baboons...

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Bibliographic Details
Published in:Virology (New York, N.Y.) N.Y.), 2015-01, Vol.474, p.186-198
Main Authors: Vatter, Heather A, Donaldson, Eric F, Huynh, Jeremy, Rawlings, Stephanie, Manoharan, Minsha, Legasse, Alfred, Planer, Shannon, Dickerson, Mary F, Lewis, Anne D, Colgin, Lois M.A, Axthelm, Michael K, Pecotte, Jerilyn K, Baric, Ralph S, Wong, Scott W, Brinton, Margo A
Format: Article
Language:English
Subjects:
Animals
Arterivirus - genetics
Arterivirus - isolation & purification
Arterivirus - pathogenicity
Arterivirus Infections - pathology
Arterivirus Infections - veterinary
Arterivirus Infections - virology
Baboon
Coagulopathy
Cytokines - blood
Genome, Viral
Hemorrhagic fever disease
Hemorrhagic Fevers, Viral - pathology
Hemorrhagic Fevers, Viral - veterinary
Hemorrhagic Fevers, Viral - virology
Host-Pathogen Interactions
Infectious Disease
Japanese macaque
Macaca
Monkey Diseases - immunology
Monkey Diseases - pathology
Monkey Diseases - virology
Organ Specificity
Papio
Papio - virology
Persistent infection
Simian hemorrhagic fever virus
Viremia - veterinary
Viremia - virology
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Summary:Abstract Simian hemorrhagic fever virus is an arterivirus that naturally infects species of African nonhuman primates causing acute or persistent asymptomatic infections. Although it was previously estimated that 1% of baboons are SHFV-positive, more than 10% of wild-caught and captive-bred baboons tested were SHFV positive and the infections persisted for more than 10 years with detectable virus in the blood (100–1000 genomes/ml). The sequences of two baboon SHFV isolates that were amplified by a single passage in primary macaque macrophages had a high degree of identity to each other as well as to the genome of SHFV-LVR, a laboratory strain isolated in the 1960s. Infection of Japanese macaques with 100 PFU of a baboon isolate consistently produced high level viremia, pro-inflammatory cytokines, elevated tissue factor levels and clinical signs indicating coagulation defects. The baboon virus isolate provides a reliable BSL2 model of viral hemorrhagic fever disease in macaques.
ISSN:0042-6822
1096-0341
DOI:10.1016/j.virol.2014.10.018