Gene expression profile differences in gastric cancer, pericancerous epithelium and normal gastric mucosa by gene chip

AIM: To study the difference of gene expression in gastric cancer (T), pericancerous epithelium (P) and normal tissue of gastric mucosa (C), and to screen an associated novel gene in eady gastric carcinogenesis by oligonucleotide microarray. METHODS: U133A (Affymetrix, Santa Clara, CA) gene chip was...

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Bibliographic Details
Published in:World journal of gastroenterology : WJG 2005-04, Vol.11 (16), p.2390-2397
Main Authors: Yu, Chuan-Ding, Xu, Shen-Hua, Mou, Hang-Zhou, Jiang, Zhi-Ming, Zhu, Chi-Hong, Liu, Xiang-Lin
Format: Article
Language:English
Subjects:
Epithelium - physiology
Female
Gastric Cancer
Gastric Mucosa - physiology
Gene Expression Profiling - methods
Gene Expression Regulation, Neoplastic
Humans
Male
Middle Aged
Oligonucleotide Array Sequence Analysis
Precancerous Conditions - genetics
Stomach Neoplasms - genetics
上皮细胞
基因芯片
基因表达
胃肿瘤
胃黏膜
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Summary:AIM: To study the difference of gene expression in gastric cancer (T), pericancerous epithelium (P) and normal tissue of gastric mucosa (C), and to screen an associated novel gene in eady gastric carcinogenesis by oligonucleotide microarray. METHODS: U133A (Affymetrix, Santa Clara, CA) gene chip was used to detect the gene expression profile difference in T, P and C, respectively. Bioinformatics was used to analyze the detected results. RESULTS: When gastric cancer was compared with normal gastric mucosa, 766 genes were found, with a difference of more than four times in expression levels. Of the 766 genes, 530 were up-regulated (Signal Log Ratio [SLR]>2), and 236 were down-regulated (SLR2), and 14 were down-regulated (SLR2), and 35 were down-regulated (SLR
ISSN:1007-9327
2219-2840
DOI:10.3748/wjg.v11.i16.2390