Amylase level in extrahepatic bile duct in adult patients with choledochal cyst plus anomalous pancreatico-biliary ductal union

AIM: To investigate the relationship between pancreatic amylase in bile duct and the clinico-pathological features in adult patients with choledochal cyst and anomalous pancreatico-biliary ductal union (APBDU). METHODS: From 39 patients who underwent surgery for choledochal cyst between March 1995 a...

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Published in:World journal of gastroenterology : WJG 2005-04, Vol.11 (13), p.1965-1970
Main Authors: Jeong, In-Ho, Jung, Yong-Sik, Kim, Hong, Kim, Bong-Wan, Kim, Jung-Woon, Hong, Jeong, Wang, Hee-Jung, Kim, Myung-Wook, Yoo, Byung-Moo, Kim, Jin-Hong, Han, Jae-Ho, Kim, Wook-Hwan
Format: Article
Language:English
Subjects:
Adult
Amylases - metabolism
Choledochal Cyst - metabolism
Choledochal Cyst - pathology
Choledochal Cyst - surgery
Clinical Research
Common Bile Duct - abnormalities
Common Bile Duct - enzymology
Common Bile Duct - pathology
Female
Humans
Hyperplasia
Lipase - metabolism
Male
Middle Aged
Pancreatic Ducts - abnormalities
Retrospective Studies
淀粉酶
肝外胆管
胆总管囊肿
胆汁输送
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cited_by cdi_FETCH-LOGICAL-c450t-876d41a45a27011d839a440ec2864af6773622f9922fbbe73fbb5b24f8331e833
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container_issue 13
container_start_page 1965
container_title World journal of gastroenterology : WJG
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creator Jeong, In-Ho
Jung, Yong-Sik
Kim, Hong
Kim, Bong-Wan
Kim, Jung-Woon
Hong, Jeong
Wang, Hee-Jung
Kim, Myung-Wook
Yoo, Byung-Moo
Kim, Jin-Hong
Han, Jae-Ho
Kim, Wook-Hwan
description AIM: To investigate the relationship between pancreatic amylase in bile duct and the clinico-pathological features in adult patients with choledochal cyst and anomalous pancreatico-biliary ductal union (APBDU). METHODS: From 39 patients who underwent surgery for choledochal cyst between March 1995 and March 2003, we selected 15 adult patients who had some symptoms and were radiologically diagnosed as APBDU, and their clinico-pathological features were subsequently evaluated retrospectively. However, we could not obtain biliary amylase in all the patients because of the surgeon's slip. Therefore, we measured the amylase level in gall bladder of 10 patients and in common bile duct of 11 patients. RESULTS: Levels of amylase in common bile duct and gall bladder ranged from 11 500 to 212 000 IU/L, and the younger the patients, the higher the biliary amylase level (r = -0.982, P
doi_str_mv 10.3748/wjg.v11.i13.1965
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METHODS: From 39 patients who underwent surgery for choledochal cyst between March 1995 and March 2003, we selected 15 adult patients who had some symptoms and were radiologically diagnosed as APBDU, and their clinico-pathological features were subsequently evaluated retrospectively. However, we could not obtain biliary amylase in all the patients because of the surgeon's slip. Therefore, we measured the amylase level in gall bladder of 10 patients and in common bile duct of 11 patients. RESULTS: Levels of amylase in common bile duct and gall bladder ranged from 11 500 to 212 000 IU/L, and the younger the patients, the higher the biliary amylase level (r = -0.982, P&lt;0.01). Pathologically, significant correlation was found between the size of choledochal cyst and the grade of inflammation (r= 0.798, P&lt;0.01). And, significant correlation was found between the level of amylase in gall bladder and the grade of hyperplasia. On the other hand, there was no correlation to the age of symptomatic onset or inflammatory grade (r = 0.743, P&lt;0.05). Level of lipase was elevated from 6 000 to 159 000 IU/L in bile duct and from 14 400 to 117 000 IU/L in the gall bladder; however, there was no significant correlation with age or clinico-pathological features. CONCLUSION: The results support the notion that amylase has a particular role in the onset of symptoms, and suggest that a large amount of biliary amylase induces early onset of symptom, thereby making early diagnosis possible.</description><identifier>ISSN: 1007-9327</identifier><identifier>EISSN: 2219-2840</identifier><identifier>DOI: 10.3748/wjg.v11.i13.1965</identifier><identifier>PMID: 15800987</identifier><language>eng</language><publisher>United States: Department of Surgery,Ajou University School of Medicine,Suwon,Korea%Department of Gastroenterology,Ajou University School of Medicine,Suwon,Korea%Department of Pathology,Ajou University School of Medicine,Suwon,Korea</publisher><subject>Adult ; Amylases - metabolism ; Choledochal Cyst - metabolism ; Choledochal Cyst - pathology ; Choledochal Cyst - surgery ; Clinical Research ; Common Bile Duct - abnormalities ; Common Bile Duct - enzymology ; Common Bile Duct - pathology ; Female ; Humans ; Hyperplasia ; Lipase - metabolism ; Male ; Middle Aged ; Pancreatic Ducts - abnormalities ; Retrospective Studies ; 淀粉酶 ; 肝外胆管 ; 胆总管囊肿 ; 胆汁输送</subject><ispartof>World journal of gastroenterology : WJG, 2005-04, Vol.11 (13), p.1965-1970</ispartof><rights>Copyright © Wanfang Data Co. Ltd. All Rights Reserved.</rights><rights>2005 Baishideng Publishing Group Inc. All rights reserved. 2005</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c450t-876d41a45a27011d839a440ec2864af6773622f9922fbbe73fbb5b24f8331e833</citedby><cites>FETCH-LOGICAL-c450t-876d41a45a27011d839a440ec2864af6773622f9922fbbe73fbb5b24f8331e833</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/84123X/84123X.jpg</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4305718/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4305718/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15800987$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jeong, In-Ho</creatorcontrib><creatorcontrib>Jung, Yong-Sik</creatorcontrib><creatorcontrib>Kim, Hong</creatorcontrib><creatorcontrib>Kim, Bong-Wan</creatorcontrib><creatorcontrib>Kim, Jung-Woon</creatorcontrib><creatorcontrib>Hong, Jeong</creatorcontrib><creatorcontrib>Wang, Hee-Jung</creatorcontrib><creatorcontrib>Kim, Myung-Wook</creatorcontrib><creatorcontrib>Yoo, Byung-Moo</creatorcontrib><creatorcontrib>Kim, Jin-Hong</creatorcontrib><creatorcontrib>Han, Jae-Ho</creatorcontrib><creatorcontrib>Kim, Wook-Hwan</creatorcontrib><title>Amylase level in extrahepatic bile duct in adult patients with choledochal cyst plus anomalous pancreatico-biliary ductal union</title><title>World journal of gastroenterology : WJG</title><addtitle>World Journal of Gastroenterology</addtitle><description>AIM: To investigate the relationship between pancreatic amylase in bile duct and the clinico-pathological features in adult patients with choledochal cyst and anomalous pancreatico-biliary ductal union (APBDU). 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METHODS: From 39 patients who underwent surgery for choledochal cyst between March 1995 and March 2003, we selected 15 adult patients who had some symptoms and were radiologically diagnosed as APBDU, and their clinico-pathological features were subsequently evaluated retrospectively. However, we could not obtain biliary amylase in all the patients because of the surgeon's slip. Therefore, we measured the amylase level in gall bladder of 10 patients and in common bile duct of 11 patients. RESULTS: Levels of amylase in common bile duct and gall bladder ranged from 11 500 to 212 000 IU/L, and the younger the patients, the higher the biliary amylase level (r = -0.982, P&lt;0.01). Pathologically, significant correlation was found between the size of choledochal cyst and the grade of inflammation (r= 0.798, P&lt;0.01). And, significant correlation was found between the level of amylase in gall bladder and the grade of hyperplasia. On the other hand, there was no correlation to the age of symptomatic onset or inflammatory grade (r = 0.743, P&lt;0.05). Level of lipase was elevated from 6 000 to 159 000 IU/L in bile duct and from 14 400 to 117 000 IU/L in the gall bladder; however, there was no significant correlation with age or clinico-pathological features. CONCLUSION: The results support the notion that amylase has a particular role in the onset of symptoms, and suggest that a large amount of biliary amylase induces early onset of symptom, thereby making early diagnosis possible.</abstract><cop>United States</cop><pub>Department of Surgery,Ajou University School of Medicine,Suwon,Korea%Department of Gastroenterology,Ajou University School of Medicine,Suwon,Korea%Department of Pathology,Ajou University School of Medicine,Suwon,Korea</pub><pmid>15800987</pmid><doi>10.3748/wjg.v11.i13.1965</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record>
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ispartof World journal of gastroenterology : WJG, 2005-04, Vol.11 (13), p.1965-1970
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subjects Adult
Amylases - metabolism
Choledochal Cyst - metabolism
Choledochal Cyst - pathology
Choledochal Cyst - surgery
Clinical Research
Common Bile Duct - abnormalities
Common Bile Duct - enzymology
Common Bile Duct - pathology
Female
Humans
Hyperplasia
Lipase - metabolism
Male
Middle Aged
Pancreatic Ducts - abnormalities
Retrospective Studies
淀粉酶
肝外胆管
胆总管囊肿
胆汁输送
title Amylase level in extrahepatic bile duct in adult patients with choledochal cyst plus anomalous pancreatico-biliary ductal union
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