Liver fibrosis caused by choledocholith to regress after biliary drainage

• Published in: World journal of gastroenterology : WJG 2005-04, Vol.11 (13), p.2013-2015
• Main Authors: Chen, Zuo-Bing, Zheng, Shu-Sen, Hu, Guo-Zhi, Gao, Yuan, Ding, Chen-Yan, Zhang, Yun, Zhao, Xue-Hong, Ni, Lin-Mei
• Format: Article
• Language: English
• Subjects: Adult; Bile Ducts; Brief Reports; Choledocholithiasis - complications; Choledocholithiasis - pathology; Choledocholithiasis - surgery; Drainage; Female; Follow-Up Studies; Humans; Liver Cirrhosis - etiology; Liver Cirrhosis - pathology; Liver Cirrhosis - surgery; Male; Middle Aged; Retrospective Studies; Severity of Illness Index; 病理机制; 肝纤维化; 胆总管结石; 胆汁排泄
• ISSN: 1007-9327; 2219-2840
• DOI: 10.3748/wjg.v11.i13.2013

AIM: To study the correlation between liver fibrosis severity and biliary drainage in patients with choledocholith. METHODS: A follow-up study on seven patients with liver fibrosis due to choledocholith was made. The data, including biochemical tests (aspartate aminotransferase, alanine aminotransferase) and liver histological features befor eand after biliary drainage, were collected and studied. The fibrosis severity was scored on a scale from 0 to 3, with 0 denoting none, 1 portal and periportal fibrosis, 2 the presence of numerous fiber septa, and 3 cirrhosis. The average liver fibrosis severity scores of the first and second biopsy were compared with statistical method. RESULTS: The first, second liver fibrosis severity scores of these seven patients were 2,1; 2,1; 1,0; 1,1; 2,1; 2,1; 1,0 respectively. The results showed that the average liver fibrosis severity score of the second liver biopsy decreased significantly compared with the first liver biopsy (n = 7, t = 4.25, P