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Influence of various proton pump inhibitors on intestinal metaplasia in noneradicated Helicobacter pylori patients
Intestinal metaplasia (IM) is more often found in patients with Helicobacter pylori (H pylori) infection, while eradication of H pylori results in significant reduction in the severity and activity of chronic gastritis. We aimed to determine in patients with unsuccessful eradication of H pylori the...
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| Published in: | World journal of gastroenterology : WJG 2005-04, Vol.11 (15), p.2334-2336 |
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| Main Authors: | , , , , |
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| cited_by | cdi_FETCH-LOGICAL-c352t-7ed95ac642aac208549b840ea961966ca610359d8274cc8e2cb2dceb1fee293a3 |
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| cites | cdi_FETCH-LOGICAL-c352t-7ed95ac642aac208549b840ea961966ca610359d8274cc8e2cb2dceb1fee293a3 |
| container_end_page | 2336 |
| container_issue | 15 |
| container_start_page | 2334 |
| container_title | World journal of gastroenterology : WJG |
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| creator | Marusic, Marinko Babic, Zarko Nesanovic, Mirjana Lucijanic-Mlinac, Mira Stajcar, Vesna |
| description | Intestinal metaplasia (IM) is more often found in patients with Helicobacter pylori (H pylori) infection, while eradication of H pylori results in significant reduction in the severity and activity of chronic gastritis. We aimed to determine in patients with unsuccessful eradication of H pylori the role of various proton pump inhibitors (PPIs) having different mechanisms in the resolution of IM.
We confirmed endoscopically and pathohistologically (Sydney classification) the IM in 335 patients with gastritis before and after medication for eradication of H pylori (Maastricht Protocol 2002). H pylori infection was determined by using histology, urease test and culture. Control endoscopy and histology were done after 30 d and thereafter (within 1 year). Unsuccessful eradication was considered if only one of the three tests (histology, urease and culture) was negative after therapy protocol. We used omeprazole, pantoprazole, lansoprazole in therapy protocols (in combination with two antibiotics).
We found no significant difference in resolution of IM by using different PPI between the groups of eradicated and noneradicated patients (P |
| doi_str_mv | 10.3748/wjg.v11.i15.2334 |
| format | article |
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We confirmed endoscopically and pathohistologically (Sydney classification) the IM in 335 patients with gastritis before and after medication for eradication of H pylori (Maastricht Protocol 2002). H pylori infection was determined by using histology, urease test and culture. Control endoscopy and histology were done after 30 d and thereafter (within 1 year). Unsuccessful eradication was considered if only one of the three tests (histology, urease and culture) was negative after therapy protocol. We used omeprazole, pantoprazole, lansoprazole in therapy protocols (in combination with two antibiotics).
We found no significant difference in resolution of IM by using different PPI between the groups of eradicated and noneradicated patients (P<0.4821 and P<0.4388, respectively).
There is no significant difference in resolution of intestinal metaplasia by different proton pump inhibitors.</description><identifier>ISSN: 1007-9327</identifier><identifier>EISSN: 2219-2840</identifier><identifier>DOI: 10.3748/wjg.v11.i15.2334</identifier><identifier>PMID: 15818748</identifier><language>eng</language><publisher>United States: Baishideng Publishing Group Inc</publisher><subject>2-Pyridinylmethylsulfinylbenzimidazoles ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Benzimidazoles - therapeutic use ; Brief Reports ; Chronic Disease ; Enzyme Inhibitors - therapeutic use ; Female ; Gastritis - drug therapy ; Gastritis - microbiology ; Gastritis - pathology ; Helicobacter Infections - drug therapy ; Helicobacter Infections - pathology ; Helicobacter pylori ; Humans ; Intestines - pathology ; Lansoprazole ; Male ; Metaplasia ; Middle Aged ; Omeprazole - analogs & derivatives ; Omeprazole - therapeutic use ; Pantoprazole ; Proton Pump Inhibitors ; Sulfoxides - therapeutic use</subject><ispartof>World journal of gastroenterology : WJG, 2005-04, Vol.11 (15), p.2334-2336</ispartof><rights>2005 Baishideng Publishing Group Inc. All rights reserved. 2005</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c352t-7ed95ac642aac208549b840ea961966ca610359d8274cc8e2cb2dceb1fee293a3</citedby><cites>FETCH-LOGICAL-c352t-7ed95ac642aac208549b840ea961966ca610359d8274cc8e2cb2dceb1fee293a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4305821/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4305821/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27922,27923,53789,53791</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15818748$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Marusic, Marinko</creatorcontrib><creatorcontrib>Babic, Zarko</creatorcontrib><creatorcontrib>Nesanovic, Mirjana</creatorcontrib><creatorcontrib>Lucijanic-Mlinac, Mira</creatorcontrib><creatorcontrib>Stajcar, Vesna</creatorcontrib><title>Influence of various proton pump inhibitors on intestinal metaplasia in noneradicated Helicobacter pylori patients</title><title>World journal of gastroenterology : WJG</title><addtitle>World J Gastroenterol</addtitle><description>Intestinal metaplasia (IM) is more often found in patients with Helicobacter pylori (H pylori) infection, while eradication of H pylori results in significant reduction in the severity and activity of chronic gastritis. We aimed to determine in patients with unsuccessful eradication of H pylori the role of various proton pump inhibitors (PPIs) having different mechanisms in the resolution of IM.
We confirmed endoscopically and pathohistologically (Sydney classification) the IM in 335 patients with gastritis before and after medication for eradication of H pylori (Maastricht Protocol 2002). H pylori infection was determined by using histology, urease test and culture. Control endoscopy and histology were done after 30 d and thereafter (within 1 year). Unsuccessful eradication was considered if only one of the three tests (histology, urease and culture) was negative after therapy protocol. We used omeprazole, pantoprazole, lansoprazole in therapy protocols (in combination with two antibiotics).
We found no significant difference in resolution of IM by using different PPI between the groups of eradicated and noneradicated patients (P<0.4821 and P<0.4388, respectively).
There is no significant difference in resolution of intestinal metaplasia by different proton pump inhibitors.</description><subject>2-Pyridinylmethylsulfinylbenzimidazoles</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Benzimidazoles - therapeutic use</subject><subject>Brief Reports</subject><subject>Chronic Disease</subject><subject>Enzyme Inhibitors - therapeutic use</subject><subject>Female</subject><subject>Gastritis - drug therapy</subject><subject>Gastritis - microbiology</subject><subject>Gastritis - pathology</subject><subject>Helicobacter Infections - drug therapy</subject><subject>Helicobacter Infections - pathology</subject><subject>Helicobacter pylori</subject><subject>Humans</subject><subject>Intestines - pathology</subject><subject>Lansoprazole</subject><subject>Male</subject><subject>Metaplasia</subject><subject>Middle Aged</subject><subject>Omeprazole - analogs & derivatives</subject><subject>Omeprazole - therapeutic use</subject><subject>Pantoprazole</subject><subject>Proton Pump Inhibitors</subject><subject>Sulfoxides - therapeutic use</subject><issn>1007-9327</issn><issn>2219-2840</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><recordid>eNpVkc1rGzEQxUVoaBy395yCTr2tq4_9vBRKSGqDoZf0LGa1s46CVtpIWpf891WwadqTYObN05v5EXLD2UY2Zfv19_Nhc-R8Y3i1EVKWF2QlBO8K0ZbsA1lxxpqik6K5ItcxPjOWNZX4SK541fI2G6xI2LnRLug0Uj_SIwTjl0jn4JN3dF6mmRr3ZHqTfIg0l4xLGJNxYOmECWYL0UCuUucdBhiMhoQD3aI12vegEwY6v1ofDJ0hGXQpfiKXI9iIn8_vmvx6uH-82xb7nz92d9_3hc4hU9Hg0FWg61IAaMHaquz6vBZCV_OurjXUnMmqG1rRlFq3KHQvBo09HxFFJ0GuybeT77z0E-aWSwGsmoOZILwqD0b933HmSR38UZWSVa3g2eDL2SD4lyWvrSYTNVoLDvOVVN00OZeospCdhDr4GAOOfz_hTL2BUhmUyqBUBqXeQOWR23_DvQ-cycg_U7eU-Q</recordid><startdate>20050421</startdate><enddate>20050421</enddate><creator>Marusic, Marinko</creator><creator>Babic, Zarko</creator><creator>Nesanovic, Mirjana</creator><creator>Lucijanic-Mlinac, Mira</creator><creator>Stajcar, Vesna</creator><general>Baishideng Publishing Group Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20050421</creationdate><title>Influence of various proton pump inhibitors on intestinal metaplasia in noneradicated Helicobacter pylori patients</title><author>Marusic, Marinko ; Babic, Zarko ; Nesanovic, Mirjana ; Lucijanic-Mlinac, Mira ; Stajcar, Vesna</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c352t-7ed95ac642aac208549b840ea961966ca610359d8274cc8e2cb2dceb1fee293a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>2-Pyridinylmethylsulfinylbenzimidazoles</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Benzimidazoles - therapeutic use</topic><topic>Brief Reports</topic><topic>Chronic Disease</topic><topic>Enzyme Inhibitors - therapeutic use</topic><topic>Female</topic><topic>Gastritis - drug therapy</topic><topic>Gastritis - microbiology</topic><topic>Gastritis - pathology</topic><topic>Helicobacter Infections - drug therapy</topic><topic>Helicobacter Infections - pathology</topic><topic>Helicobacter pylori</topic><topic>Humans</topic><topic>Intestines - pathology</topic><topic>Lansoprazole</topic><topic>Male</topic><topic>Metaplasia</topic><topic>Middle Aged</topic><topic>Omeprazole - analogs & derivatives</topic><topic>Omeprazole - therapeutic use</topic><topic>Pantoprazole</topic><topic>Proton Pump Inhibitors</topic><topic>Sulfoxides - therapeutic use</topic><toplevel>online_resources</toplevel><creatorcontrib>Marusic, Marinko</creatorcontrib><creatorcontrib>Babic, Zarko</creatorcontrib><creatorcontrib>Nesanovic, Mirjana</creatorcontrib><creatorcontrib>Lucijanic-Mlinac, Mira</creatorcontrib><creatorcontrib>Stajcar, Vesna</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>World journal of gastroenterology : WJG</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Marusic, Marinko</au><au>Babic, Zarko</au><au>Nesanovic, Mirjana</au><au>Lucijanic-Mlinac, Mira</au><au>Stajcar, Vesna</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of various proton pump inhibitors on intestinal metaplasia in noneradicated Helicobacter pylori patients</atitle><jtitle>World journal of gastroenterology : WJG</jtitle><addtitle>World J Gastroenterol</addtitle><date>2005-04-21</date><risdate>2005</risdate><volume>11</volume><issue>15</issue><spage>2334</spage><epage>2336</epage><pages>2334-2336</pages><issn>1007-9327</issn><eissn>2219-2840</eissn><abstract>Intestinal metaplasia (IM) is more often found in patients with Helicobacter pylori (H pylori) infection, while eradication of H pylori results in significant reduction in the severity and activity of chronic gastritis. We aimed to determine in patients with unsuccessful eradication of H pylori the role of various proton pump inhibitors (PPIs) having different mechanisms in the resolution of IM.
We confirmed endoscopically and pathohistologically (Sydney classification) the IM in 335 patients with gastritis before and after medication for eradication of H pylori (Maastricht Protocol 2002). H pylori infection was determined by using histology, urease test and culture. Control endoscopy and histology were done after 30 d and thereafter (within 1 year). Unsuccessful eradication was considered if only one of the three tests (histology, urease and culture) was negative after therapy protocol. We used omeprazole, pantoprazole, lansoprazole in therapy protocols (in combination with two antibiotics).
We found no significant difference in resolution of IM by using different PPI between the groups of eradicated and noneradicated patients (P<0.4821 and P<0.4388, respectively).
There is no significant difference in resolution of intestinal metaplasia by different proton pump inhibitors.</abstract><cop>United States</cop><pub>Baishideng Publishing Group Inc</pub><pmid>15818748</pmid><doi>10.3748/wjg.v11.i15.2334</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| source | PubMed Central (Open Access) |
| subjects | 2-Pyridinylmethylsulfinylbenzimidazoles Adolescent Adult Aged Aged, 80 and over Benzimidazoles - therapeutic use Brief Reports Chronic Disease Enzyme Inhibitors - therapeutic use Female Gastritis - drug therapy Gastritis - microbiology Gastritis - pathology Helicobacter Infections - drug therapy Helicobacter Infections - pathology Helicobacter pylori Humans Intestines - pathology Lansoprazole Male Metaplasia Middle Aged Omeprazole - analogs & derivatives Omeprazole - therapeutic use Pantoprazole Proton Pump Inhibitors Sulfoxides - therapeutic use |
| title | Influence of various proton pump inhibitors on intestinal metaplasia in noneradicated Helicobacter pylori patients |
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