Helicobacter pylori eradication lowers serum homocysteine level in patients without gastric atrophy

To determine whether Helicobacter pylori (H pylori)infection caused hyperhomocysteinemia by altering serum vitamin B(12), serum folate and erythrocyte folate levels and whether eradication of this organism decreased serum homocysteine level. The study involved 73 dyspeptic H pylori-positive patients...

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Bibliographic Details
Published in:World journal of gastroenterology : WJG 2005-05, Vol.11 (18), p.2764-2767
Main Authors: Ozer, Birol, Serin, Ender, Gumurdulu, Yuksel, Kayaselcuk, Fazilet, Anarat, Ruksan, Gur, Gurden, Kul, Kemal, Guclu, Mustafa, Boyacioglu, Sedat
Format: Article
Language:English
Subjects:
Adult
Anti-Bacterial Agents
Brief Reports
Drug Therapy, Combination - therapeutic use
Dyspepsia - microbiology
Female
Helicobacter Infections - blood
Helicobacter Infections - complications
Helicobacter Infections - drug therapy
Helicobacter pylori
Homocysteine - blood
Humans
Male
Middle Aged
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Summary:To determine whether Helicobacter pylori (H pylori)infection caused hyperhomocysteinemia by altering serum vitamin B(12), serum folate and erythrocyte folate levels and whether eradication of this organism decreased serum homocysteine level. The study involved 73 dyspeptic H pylori-positive patients, none of them had gastric mucosal atrophy based on rapid urease test and histology. Out of 73 patients, 41 (56.2%) showed a successful eradication of H pylori 4 wk after the end of treatment. In these 41 patients, fasting serum vitamin B(12), folate and homocysteine levels, and erythrocyte folate levels before and 4 wk after H pylori eradication therapy were compared. The group with a successful eradication of H pylori had significantly higher serum vitamin B(12) and erythrocyte folate levels in the post-treatment period compared to those in pre-treatment period (210+/-97 pg/mL vs 237+/-94 pg/mL, P
ISSN:1007-9327
2219-2840
DOI:10.3748/wjg.v11.i18.2764