Impact of Helicobacter pylori infection on ghrelin and various neuroendocrine hormones in plasma

• Published in: World journal of gastroenterology : WJG 2005-03, Vol.11 (11), p.1644-1648
• Main Authors: Isomoto, Hajime, Ueno, Hiroaki, Nishi, Yoshito, Wen, Chun-Yang, Nakazato, Masamitsu, Kohno, Shigeru
• Format: Article
• Language: English
• Subjects: Adult; Aged; Brief Reports; Energy Metabolism; Female; Gastrins - blood; Ghrelin; Helicobacter Infections - metabolism; Helicobacter pylori; Humans; Insulin-Like Growth Factor I - metabolism; Leptin - blood; Male; Middle Aged; Neurosecretory Systems - metabolism; Peptide Hormones - blood; 幽门螺杆菌; 神经内分泌; 细菌感染
• ISSN: 1007-9327; 2219-2840
• DOI: 10.3748/wjg.v11.i11.1644

AIM: Ghrelin, an endogenous ligand for growth hormone secretagogue receptor, influences appetite, energy balance, gastric motility and acid secretion. The stomach is the main source of circulating ghrelin. There are inconsistent reports on the influence of Helicobacterpylori (Hpylon) infection on circulating ghrelin levels. We sought to elucidate the relationship between ghrelin and various peptides in plasma, with special reference to H pylori. METHODS: Plasma ghrelin levels were measured by radioimmunoassay in 89 subjects who were referred for upper gastrointestinal endoscopy, consisting of 42 H pylori infected and 47 uninfected ones. Plasma gastrin, somatostatin, leptin, insulin-like growth hormone 1 (IGF-1) and chromogranin A concentrations were also measured. Twelve patients were treated with anti- Hpyloriregimen. RESULTS: Ghrelin circulating levels were greatly decreased in H pylori-positive than negative individuals (194.2±90.2fmol/mL and 250.4±84.1 respectively, P