Impact of Helicobacter pylori infection on ghrelin and various neuroendocrine hormones in plasma

AIM: Ghrelin, an endogenous ligand for growth hormone secretagogue receptor, influences appetite, energy balance, gastric motility and acid secretion. The stomach is the main source of circulating ghrelin. There are inconsistent reports on the influence of Helicobacterpylori (Hpylon) infection on ci...

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Published in:World journal of gastroenterology : WJG 2005-03, Vol.11 (11), p.1644-1648
Main Authors: Isomoto, Hajime, Ueno, Hiroaki, Nishi, Yoshito, Wen, Chun-Yang, Nakazato, Masamitsu, Kohno, Shigeru
Format: Article
Language:English
Subjects:
Adult
Aged
Brief Reports
Energy Metabolism
Female
Gastrins - blood
Ghrelin
Helicobacter Infections - metabolism
Helicobacter pylori
Humans
Insulin-Like Growth Factor I - metabolism
Leptin - blood
Male
Middle Aged
Neurosecretory Systems - metabolism
Peptide Hormones - blood
幽门螺杆菌
神经内分泌
细菌感染
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cited_by cdi_FETCH-LOGICAL-c408t-c4e2c59b9b849ddf24466ba50e1c369e0789c54f50da724d57698ebc7f0ac35e3
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container_issue 11
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container_title World journal of gastroenterology : WJG
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creator Isomoto, Hajime
Ueno, Hiroaki
Nishi, Yoshito
Wen, Chun-Yang
Nakazato, Masamitsu
Kohno, Shigeru
description AIM: Ghrelin, an endogenous ligand for growth hormone secretagogue receptor, influences appetite, energy balance, gastric motility and acid secretion. The stomach is the main source of circulating ghrelin. There are inconsistent reports on the influence of Helicobacterpylori (Hpylon) infection on circulating ghrelin levels. We sought to elucidate the relationship between ghrelin and various peptides in plasma, with special reference to H pylori. METHODS: Plasma ghrelin levels were measured by radioimmunoassay in 89 subjects who were referred for upper gastrointestinal endoscopy, consisting of 42 H pylori infected and 47 uninfected ones. Plasma gastrin, somatostatin, leptin, insulin-like growth hormone 1 (IGF-1) and chromogranin A concentrations were also measured. Twelve patients were treated with anti- Hpyloriregimen. RESULTS: Ghrelin circulating levels were greatly decreased in H pylori-positive than negative individuals (194.2±90.2fmol/mL and 250.4±84.1 respectively, P
doi_str_mv 10.3748/wjg.v11.i11.1644
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The stomach is the main source of circulating ghrelin. There are inconsistent reports on the influence of Helicobacterpylori (Hpylon) infection on circulating ghrelin levels. We sought to elucidate the relationship between ghrelin and various peptides in plasma, with special reference to H pylori. METHODS: Plasma ghrelin levels were measured by radioimmunoassay in 89 subjects who were referred for upper gastrointestinal endoscopy, consisting of 42 H pylori infected and 47 uninfected ones. Plasma gastrin, somatostatin, leptin, insulin-like growth hormone 1 (IGF-1) and chromogranin A concentrations were also measured. Twelve patients were treated with anti- Hpyloriregimen. RESULTS: Ghrelin circulating levels were greatly decreased in H pylori-positive than negative individuals (194.2±90.2fmol/mL and 250.4±84.1 respectively, P&lt;0.05), but did not significantly alter following the cure of infection (176.5±79.5 vs 191.3±120.4). There was a significant negative correlation between circulating ghrelin and leptin levels, as well as body mass index, for the whole and uninfected population, but not in H pylori-infected patients. Plasma ghrelin concentrations correlated positively with IGF-1 in H pylori-negative group and negatively with chromogranin A in the infected group. There were no significant correlations among circulating levels of ghrelin, gastrin and somatostatin irrespective of H pylori status. CONCLUSION: H pylori infection influences plasma ghrelin dynamics and its interaction with diverse bioactive peptides involved in energy balance, growth and neuroendocrine function.</description><identifier>ISSN: 1007-9327</identifier><identifier>EISSN: 2219-2840</identifier><identifier>DOI: 10.3748/wjg.v11.i11.1644</identifier><identifier>PMID: 15786542</identifier><language>eng</language><publisher>United States: Second Department of Internal Medicine, Nagasaki University School of Medicine, Sakamoto 1-7-1, Nagasaki, Japan%Third Department of Internal Medicine, Miyazaki Medical College, Kiyotake, Miyazaki,Japan%Department of Molecular Pathology, Atomic Bomb Disease Institute, Nagasaki University School of Medicine,Sakamoto 12-4, Nagasaki, Japan</publisher><subject>Adult ; Aged ; Brief Reports ; Energy Metabolism ; Female ; Gastrins - blood ; Ghrelin ; Helicobacter Infections - metabolism ; Helicobacter pylori ; Humans ; Insulin-Like Growth Factor I - metabolism ; Leptin - blood ; Male ; Middle Aged ; Neurosecretory Systems - metabolism ; Peptide Hormones - blood ; 幽门螺杆菌 ; 神经内分泌 ; 细菌感染</subject><ispartof>World journal of gastroenterology : WJG, 2005-03, Vol.11 (11), p.1644-1648</ispartof><rights>Copyright © Wanfang Data Co. 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All rights reserved. 2005</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c408t-c4e2c59b9b849ddf24466ba50e1c369e0789c54f50da724d57698ebc7f0ac35e3</citedby><cites>FETCH-LOGICAL-c408t-c4e2c59b9b849ddf24466ba50e1c369e0789c54f50da724d57698ebc7f0ac35e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/84123X/84123X.jpg</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4305946/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4305946/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15786542$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Isomoto, Hajime</creatorcontrib><creatorcontrib>Ueno, Hiroaki</creatorcontrib><creatorcontrib>Nishi, Yoshito</creatorcontrib><creatorcontrib>Wen, Chun-Yang</creatorcontrib><creatorcontrib>Nakazato, Masamitsu</creatorcontrib><creatorcontrib>Kohno, Shigeru</creatorcontrib><title>Impact of Helicobacter pylori infection on ghrelin and various neuroendocrine hormones in plasma</title><title>World journal of gastroenterology : WJG</title><addtitle>World Journal of Gastroenterology</addtitle><description>AIM: Ghrelin, an endogenous ligand for growth hormone secretagogue receptor, influences appetite, energy balance, gastric motility and acid secretion. The stomach is the main source of circulating ghrelin. There are inconsistent reports on the influence of Helicobacterpylori (Hpylon) infection on circulating ghrelin levels. We sought to elucidate the relationship between ghrelin and various peptides in plasma, with special reference to H pylori. METHODS: Plasma ghrelin levels were measured by radioimmunoassay in 89 subjects who were referred for upper gastrointestinal endoscopy, consisting of 42 H pylori infected and 47 uninfected ones. Plasma gastrin, somatostatin, leptin, insulin-like growth hormone 1 (IGF-1) and chromogranin A concentrations were also measured. Twelve patients were treated with anti- Hpyloriregimen. RESULTS: Ghrelin circulating levels were greatly decreased in H pylori-positive than negative individuals (194.2±90.2fmol/mL and 250.4±84.1 respectively, P&lt;0.05), but did not significantly alter following the cure of infection (176.5±79.5 vs 191.3±120.4). There was a significant negative correlation between circulating ghrelin and leptin levels, as well as body mass index, for the whole and uninfected population, but not in H pylori-infected patients. Plasma ghrelin concentrations correlated positively with IGF-1 in H pylori-negative group and negatively with chromogranin A in the infected group. There were no significant correlations among circulating levels of ghrelin, gastrin and somatostatin irrespective of H pylori status. 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There was a significant negative correlation between circulating ghrelin and leptin levels, as well as body mass index, for the whole and uninfected population, but not in H pylori-infected patients. Plasma ghrelin concentrations correlated positively with IGF-1 in H pylori-negative group and negatively with chromogranin A in the infected group. There were no significant correlations among circulating levels of ghrelin, gastrin and somatostatin irrespective of H pylori status. 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identifier ISSN: 1007-9327
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subjects Adult
Aged
Brief Reports
Energy Metabolism
Female
Gastrins - blood
Ghrelin
Helicobacter Infections - metabolism
Helicobacter pylori
Humans
Insulin-Like Growth Factor I - metabolism
Leptin - blood
Male
Middle Aged
Neurosecretory Systems - metabolism
Peptide Hormones - blood
幽门螺杆菌
神经内分泌
细菌感染
title Impact of Helicobacter pylori infection on ghrelin and various neuroendocrine hormones in plasma
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