14C-urea breath test in patients undergoing anti-tuberculosis therapy

• Published in: World journal of gastroenterology : WJG 2005-03, Vol.11 (11), p.1712-1714
• Main Authors: Mirbagheri, Sayed Amir, Sohrabpour, Amir Ali, Hasibi, Mehrdad, Moghimi, Babak, Mohamadnejad, Mehdi
• Format: Article
• Language: English
• Subjects: 14C-尿素; Adolescent; Adult; Antitubercular Agents - therapeutic use; Breath Tests - methods; Brief Reports; Carbon Radioisotopes; Female; Helicobacter Infections - complications; Helicobacter Infections - diagnosis; Helicobacter Infections - drug therapy; Helicobacter pylori - isolation & purification; Humans; Male; Middle Aged; Tuberculosis, Pulmonary - complications; Tuberculosis, Pulmonary - drug therapy; Urea; 实验检测; 联合治疗; 肺结核; 药物治疗
• ISSN: 1007-9327; 2219-2840
• DOI: 10.3748/wjg.v11.i11.1712

AIM: Urea breath test (UBT) is a non-invasive diagnostic test for detecting the presence of He/icobacter py/ori (H pylori). In this study we evaluated the effect of anti-tuberculosis therapy on the results of ^14C-UBT. METHODS: Patients, with the diagnosis of tuberculosis (TB) who had a positive UBT at the point of starting antiTB therapy, were included. None had a history of peptic ulcer disease or had taken antibiotics, bismuth compounds and/or PPI in the previous month. ^14C-UBT was repeated at the end of the second month and the end of treatment period and one month after completion of treatment course. RESULTS: Thirty-five patients (23 males) were enrolled. 14C-UBT was negative in all 35 patients (100%) at the end of the second month and remained negative in 30 cases (85.7%) at the end of the treatment course. One month after completion of treatment course, UBT remained negative in 13 patients (37.1%). CONCLUSION: Our report underscores the need for caution while interpreting urea breath test results in patients undergoing anti-TB therapy. Furthermore, the combination of drugs used in this study resulted in H pylori eradication in a minority of patients.